A micropillar array for sample concentration via in-plane evaporation

Choi, Jae-Woo; Hashemi, S. Mohammad H.; Erickson, David

doi:10.1063/1.4890943

Cited by 14 publications

(9 citation statements)

References 43 publications

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“…Similar systems have been constructed for concentration of bacteria and viruses [36,37], and concentration has also been carried out using microstructured media [38][39][40] Evaporation pumps with greater capacity were subsequently developed using porous media [41][42][43], and used for 3 sample injection [44,45].…”

Section: Introductionmentioning

confidence: 99%

Rapid evaporation-driven chemical pre-concentration and separation on paper

Syms

2017

Biomicrofluidics

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Airflow-enhanced evaporation is investigated as a method for rapid chemical pre-concentration on a thin porous substrate. The mechanism is described by combining 1D models of capillary rise, chromatography and pervaporation concentration. It is shown that the effective length of the column can be shorter than its actual length, allowing concentrate to be held at a stagnation point and then released for separation, and that the Péclet number, which determines concentration performance, is determined only by the substrate properties. The differential equations are solved dynamically, and it is shown that faster concentration can be achieved during capillary filling.Experiments are carried out using chromatography paper in a ducted airflow and concentration is quantified by optical imaging of water-soluble food dyes. Good agreement with the model is obtained, and concentration factors of ≈ 100 are achieved in 10 mins using Brilliant Blue FCF.Partial separation of Brilliant Blue from Tartrazine is demonstrated immediately following concentration, on a single un-patterned substrate. The mechanism may provide a method for improving the sensitivity of lab-on-paper devices.

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Section: Introductionmentioning

confidence: 99%

Rapid evaporation-driven chemical pre-concentration and separation on paper

Syms

2017

Biomicrofluidics

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“…This approach is very simple and does not harm cells, but is effective only for motile cells. 18 As a compromising approach, evaporation-assisted cellconcentrating devices were introduced 19,20 with the following advantages: they require no external energy sources, provide an active approach by adjusting evaporation rates, do not harm target cells, and are free from the motility of microorganisms. Therefore, it seems that they take the advantages of the previous approaches.…”

Section: Introductionmentioning

confidence: 99%

“…19 Similarly, micropillar structures fabricated by standard photolithography techniques have been used for the same purpose as the membrane, resulting in the concentration of target samples ranging from 100 nm to 1 μm. 20 However, membrane-integrated microfluidic devices show weaknesses in robustness, repeatability, fluid sealing, etc. Batch-processed micropillar structures were developed to resolve some of these problems.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled particle membranes for in situ concentration and chemostat-like cultivation of microorganisms on a chip

et al. 2016

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Recently, microparticles have been used as nanoporous membranes in microfluidic devices, contributing to various bioassays on a chip. Here, we report a self-assembled particle membrane (SAPM) integrated microfluidic device that concentrates particles into an aimed microchamber array by using evaporation-driven capillary forces, and manipulates the chemical environment of the microchamber array by sequentially introducing different solutions. We demonstrate that the SAPM-integrated microchamber array can concentrate microparticles and microbial cells up to 120-fold for 2 h and 35-fold for 1 h, respectively, resulting in remarkably high concentration factors. Additionally, we demonstrate that the microchamber array has high potential as a chemostat-like bioreactor because it can actively manipulate the initial seeding number of bacterial cells and continuously supply and sequentially switch fresh nutrients to them. As an example of various applications, the chemostat-like bioreactor was used as a microbial biosensor platform that enabled microbial sensor cells to respond more efficiently and rapidly to external stimuli, such as heavy metal ions. This was made possible by almost eliminating the initial lag phase that dramatically shortened the whole assay time. Notably, the SAPM-integrated microchamber array not only facilitates various bioassays on a chip but also provides unprecedented experimental platforms to study microorganisms in a simple and convenient manner.

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“…Microfluidic systems such as the ones described in b can take advantage of short path lengths for ion transport and easy incorporation of components via standard microfabrication techniques. The complex system described in c shows several approaches that can be used to improve solar-hydrogen generators: a self-tracking solar concentrator that can be used to reduce materials utilization and improve efficiency (119), heat management schemes that can be implemented to reuse heat to prepare the water feed prior to electrolysis (123), and water-splitting systems using water vapor as the feed (image courtesy of Volker Zagolla, SHINE project, EPFL). Abbreviation: PEC: photo-electrochemical.…”

Section: Figurementioning

confidence: 99%

An Integrated Device View on Photo-Electrochemical Solar-Hydrogen Generation

Modestino

Haussener

2015

Annu. Rev. Chem. Biomol. Eng.

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Devices that directly capture and store solar energy have the potential to significantly increase the share of energy from intermittent renewable sources. Photo-electrochemical solar-hydrogen generators could become an important contributor, as these devices can convert solar energy into fuels that can be used throughout all sectors of energy. Rather than focusing on scientific achievement on the component level, this article reviews aspects of overall component integration in photo-electrochemical water-splitting devices that ultimately can lead to deployable devices. Throughout the article, three generalized categories of devices are considered with different levels of integration and spanning the range of complete integration by one-material photo-electrochemical approaches to complete decoupling by photovoltaics and electrolyzer devices. By using this generalized framework, we describe the physical aspects, device requirements, and practical implications involved with developing practical photo-electrochemical water-splitting devices. Aspects reviewed include macroscopic coupled multiphysics device models, physical device demonstrations, and economic and life cycle assessments, providing the grounds to draw conclusions on the overall technological outlook.

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A micropillar array for sample concentration via in-plane evaporation

Cited by 14 publications

References 43 publications

Rapid evaporation-driven chemical pre-concentration and separation on paper

Rapid evaporation-driven chemical pre-concentration and separation on paper

Self-assembled particle membranes for in situ concentration and chemostat-like cultivation of microorganisms on a chip

An Integrated Device View on Photo-Electrochemical Solar-Hydrogen Generation

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