A Microradiographic and Chemical Comparison of in vitro Systems for the Simulation of Incipient Caries in Abraded Bovine Enamel

Pearce, E.I.F.

doi:10.1177/00220345830620091101

Cited by 42 publications

(51 citation statements)

References 21 publications

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“…Previous studies have demonstrated that an aqueous phase unsaturated with respect to both hydroxyapatite and fluorapatite erodes the enamel irrespective of the fluoride concentration in contrast to a solution unsaturated with respect to hydroxyapatite and supersaturated with respect to fluorapatite that results in a caries-like lesion [Larsen, 1972[Larsen, , 1973ten Cate and Duijsters, 1983;Pearce, 1983;Margolis et al, 1986]. The supersaturation with respect to fluorapatite induces an uptake of fluoride in the surface enamel through fluorhydroxyapatite formation [Larsen, 1973;Pearce, 1983], resulting in preservation of the surface layer. In the present study, all soft drinks were strongly unsaturated with respect to both hydroxyapatite and fluorapatite (table 3).…”

Section: Discussionmentioning

confidence: 99%

“…The experimental background for the effect of fluoride in the caries process is that as enamel dissolves due to an undersaturation with respect to hydroxyapatite the aqueous phase remains supersaturated with respect to fluorapatite which is formed in the surface layers of the enamel [Larsen, 1973[Larsen, , 1974. The more supersaturated with respect to fluorapatite the thicker and more mineralized becomes the surface layer and the less demineralized the lesion body enamel [Larsen, 1974;ten Cate and Duijsters, 1983;Pearce, 1983]. When the aqueous phase is unsaturated with respect to fluorapatite a surface layer is not formed at all and the lesion developed is therefore not a caries-like lesion.…”

mentioning

confidence: 99%

“…When the aqueous phase is unsaturated with respect to fluorapatite a surface layer is not formed at all and the lesion developed is therefore not a caries-like lesion. It is an erosion [Larsen, 1974;Pearce, 1983].…”

mentioning

confidence: 99%

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Prevention by Means of Fluoride of Enamel Erosion as Caused by Soft Drinks and Orange Juice

Larsen¹

2001

Caries Res

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Fluoride has been suggested to prevent erosion of the teeth, either after a topical treatment of the teeth or by addition of fluoride to the acidic drink. The main aim of the present study was to describe the dissolution of calcium fluoride in some soft drinks and orange juice and compare it with the amounts of calcium fluoride left on the enamel surfaces after a topical treatment. A further aim was to describe the dissolution of enamel in soft drinks and juice saturated for 3 days with solid calcium fluoride. Solid calcium fluoride was suspended in each of 10 soft drinks and orange juices and gently agitated for 72 h, after which the drinks were analyzed for calcium, phosphate and fluoride and pH was determined. To examine the erosion–preventive effect of the calcium fluoride–rich drink, intact teeth were exposed to the drinks with or without calcium fluoride. It was found that from 6 to 45 mg of calcium fluoride was dissolved per liter of drink. The more acidic the drink, the more calcium fluoride was dissolved, presumably due to HF formation. The teeth exposed to the soft drinks all showed erosion–like lesions. Very little effect of the 4–6 ppm ionic fluoride dissolved in the soft drinks was observed. In orange juice, however, the dissolved calcium fluoride established a saturation with respect to fluorapatite and consequently, the erosion–like lesion was replaced by a caries–like lesion. In conclusion, the acidic soft drinks are capable of dissolving considerable amounts of calcium fluoride and the erosion–preventive effect of even high fluoride concentrations is limited.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Prevention by Means of Fluoride of Enamel Erosion as Caused by Soft Drinks and Orange Juice

Larsen¹

2001

Caries Res

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“…Various gel systems have been used in studies of enamel demineralization [Gray and Francis, 1963;Manson-Hing et al, 1972;Ingram and Silverstone, 1981;Pearce, 1983], including gelatin gels con taining lactic acid which produce incipient caries of enamel that mimic natural le sions [Silverstone, 1966]. The ultrastructu-ral characteristics of the incipient enamel lesion are directly attributable to reminer alization within the lesion during lesion progression or partial regression.…”

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confidence: 99%

Chemical and Physical Evaluation of Dialyzed-Reconstituted Acidified Gelatin Surface Lesions of Human Enamel

1985

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Innate calcium, phosphate, and fluoride were removed from gelatin gels by dialysis. Gels were reconstituted to 25% (w/v) gelatin to contain 75 mM lactic acid, 25 mM acetic acid, desired concentration of calcium, phosphate, and fluoride, all at pH 4.2. Human enamel surfaces, 0.15 cm² each, were interfaced 96 days with 200 μl gel. Demineralization-remineralization were evaluated by calcium and phosphate analysis, hardness-like tests, and polarized-light microscopy. Fluoride (0.25 mM) alone in gels and with added calicum and phosphate enhanced remineralization and reduced enamel surface demineralization.

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“…The reason for taking scans in triplicate was the observation [de Groot et al, 1986] that caries lesions in intact human enamel are often inhomogeneous. Abraded bovine enamel demineralizes more homogeneously [Pearce, 1983;ten Cate and Duysters, 1983], al though inhomogeneity has been reported for these preparations too [ten Bosch et al, 1984]. The scans were chosen near the separation notch lying between the treated and nontreated enamel areas.…”

Section: Caries Lesion Formation and Microradiographymentioning

confidence: 99%

Effects of Surface-Active Compounds on the Demineralization of Dental Enamel

Borggreven

Driessens²,

Hoeks³

et al. 1989

Caries Res

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Slices of bovine enamel and intact human enamel were treated with (a) a two-step treatment consisting of phytate followed by hexadecyl amine, or (b) 2–O-stearoylglycerol-1,3-diphosphate (Glydip), or (c) phosphatidic acid. The effect of these agents on the rate of caries lesion formation and on the permeability of dental enamel was quantitatively determined. Glydip had the most pronounced effect on lesion formation and showed a strong inhibiting effect on the rate of demineralization, combined with a reduction of the permeability. The results indicate that at least a part of the effect of Glydip on the demineralization was caused by a reduction of the rate of dissolution of the enamel mineral. The reduction in permeability may have had an additional effect.

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A Microradiographic and Chemical Comparison of in vitro Systems for the Simulation of Incipient Caries in Abraded Bovine Enamel

Cited by 42 publications

References 21 publications

Prevention by Means of Fluoride of Enamel Erosion as Caused by Soft Drinks and Orange Juice

Prevention by Means of Fluoride of Enamel Erosion as Caused by Soft Drinks and Orange Juice

Chemical and Physical Evaluation of Dialyzed-Reconstituted Acidified Gelatin Surface Lesions of Human Enamel

Effects of Surface-Active Compounds on the Demineralization of Dental Enamel

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