A microstructure-based modeling approach to assess aging-sensitive mechanics of human intervertebral disc

Kandil, Karim; Zaïri, Fahmi; Messager, Tanguy; Zaïri, Fahed

doi:10.1016/j.cmpb.2020.105890

Cited by 8 publications

(2 citation statements)

References 72 publications

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“…In addition, the material properties of the suboptimal healthy disc were consistent with those of young healthy disc according to previous studies. [26][27][28]…”

Section: Development Of the Suboptimal Healthy Intervertebral Disc Modelmentioning

confidence: 99%

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Biomechanical effect of age-related structural changes on cervical intervertebral disc: A finite element study

Zeng

Zheng

et al. 2022

Proc Inst Mech Eng H

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Previous literature has investigated the biomechanical response of healthy and degenerative discs, but the biomechanical response of suboptimal healthy intervertebral discs received less attention. The purpose was to compare the biomechanical responses and risk of herniation of young healthy, suboptimal healthy, and degenerative intervertebral discs. A cervical spine model was established and validated using the finite element method. Suboptimal healthy, mildly, moderately, and severely degenerative disc models were developed. Disc height deformation, range of motion, intradiscal pressure, and von Mises stress in annulus fibrosus were analyzed by applying a moment of 4 Nm in flexion, extension, lateral bending, and axial rotation with 100 N compressive loads. Disc height deformation in young healthy, suboptimal healthy, mildly, moderately, and severely degenerative discs was 40%, 37%, 21%, 12%, and 8%, respectively. The decreasing order of the range of motion was young healthy spine > suboptimal healthy spine > mildly degenerative spine > moderately degenerative spine > severely degenerative spine. The mean stress of annulus ground substance in the suboptimal healthy disc was higher than in the young healthy disc. The mean stress of inter-lamellar matrix and annulus ground substance in moderately and severely degenerative discs was higher than in other discs. Age-related structural changes and degenerative changes increased the stiffness and reduced the elastic deformation of intervertebral discs. Decreased range of motion due to the effects of aging or degeneration on the intervertebral disc, may cause compensation of adjacent segments and lead to progressive degeneration of multiple segments. The effect of aging on the intervertebral disc increased the risk of annulus fibrosus damage from the biomechanical point of view. Moderately and severely degenerative discs may have a higher risk of herniation due to the higher risk of damage and layers separation of annulus fibrosus caused by increased stress in the annulus ground substance and inter-lamellar matrix.

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“…In addition, the material properties of the suboptimal healthy disc were consistent with those of young healthy disc according to previous studies. [26][27][28]…”

Section: Development Of the Suboptimal Healthy Intervertebral Disc Modelmentioning

confidence: 99%

“…Researchers showed a very weak correlation between disc material properties. [26][27][28] However, aging has significant effects on intervertebral discs on a histological and anatomical level. Yukawa et al 29 showed that disc height in older adults was about 10%-12% lower than in younger people.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical effect of age-related structural changes on cervical intervertebral disc: A finite element study

Zeng

Zheng

et al. 2022

Proc Inst Mech Eng H

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A Microstructure-Based Mechanistic Approach to Detect Degeneration Effects on Potential Damage Zones and Morphology of Young and Old Human Intervertebral Discs

Kandil

Zaïri

2023

Ann Biomed Eng

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A swelling-based biphasic analysis on the quasi-static biomechanical behaviors of healthy and degenerative intervertebral discs

Sun

Teng

et al. 2023

Computer Methods and Programs in Biomedicine

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A microstructure-based modeling approach to assess aging-sensitive mechanics of human intervertebral disc

Cited by 8 publications

References 72 publications

Biomechanical effect of age-related structural changes on cervical intervertebral disc: A finite element study

Biomechanical effect of age-related structural changes on cervical intervertebral disc: A finite element study

A Microstructure-Based Mechanistic Approach to Detect Degeneration Effects on Potential Damage Zones and Morphology of Young and Old Human Intervertebral Discs

A swelling-based biphasic analysis on the quasi-static biomechanical behaviors of healthy and degenerative intervertebral discs

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