A Middle-Aged Woman with Recurrent Respiratory Infections

Chmura, Kathryn; Chan, Edward D.; Noone, Peadar G.; Zariwala, Maimoona B; Winn, Robert A.; Knowles, Michael R.; Iseman, Michael D.; Gardner, Edward M.

doi:10.1159/000086260

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…It is not surprising that early pneumonia in patients with bronchiectasis increases the possibility of ongoing underlying conditions, particularly PCD [32]. Children with congenital immune defects have more severe and more easily identified clinical features than those with PCD [19].…”

Section: Discussionmentioning

confidence: 99%

A Descriptive Study of Non-Cystic Fibrosis Bronchiectasis in a Pediatric Population from Central and Southern Italy

et al. 2008

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Background: Non-cystic fibrosis (CF) bronchiectasis is now identified more often than in the past. Objectives: It was the aim of this study to assess the high-resolution computed tomography (HRCT) localization and extent of bronchiectasis and to determine whether asthma status, atopy and bronchiectasis distribution are associated with the etiology of bronchiectasis. Methods: We retrospectively analyzed clinical, laboratory, functional and HRCT data of 105 children with non-CF bronchiectasis at 2 tertiary respiratory units in Italy. Forty cases had bronchiectasis associated with ongoing underlying conditions, namely primary ciliary dyskinesia, primary immunodeficiency or aspiration. Results: Age at the onset of chronic cough/wheeze and at the first X-ray-documented pneumonia as well as atopy prevalence were lower in patients with ongoing underlying conditions than in those without (p = 0.049, p = 0.003 and p = 0.0008, respectively). In most cases, bronchiectasis was multilobar, and a mean of 2.5 lobes were involved. The right side was more often involved than the left (88 vs. 70%; p = 0.002), and the upper lobes were relatively spared (p < 0.000001). Right lung involvement and multilobar disease were more prevalent in children younger than 2 years at first pneumonia (p < 0.05). Conclusions: Clinical information combined with laboratory data provides additional insights into the characteristics of non-CF bronchiectasis in a large population of Italian children. This study highlights the need for longitudinal evaluations, also using HRCT, of severe and non-resolving pneumonia in children.

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Section: Discussionmentioning

confidence: 99%

A Descriptive Study of Non-Cystic Fibrosis Bronchiectasis in a Pediatric Population from Central and Southern Italy

et al. 2008

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“…Although Haemophilus influenzae, Staphylococcus aureus, and smooth strains of Pseudomonas aeruginosa are commonly seen in children with PCD, infection or colonization with mucoid strains of P. aeruginosa and NTM does not typically occur until adulthood. 28,29 In a case series of PCD patients from a referral center, 5 of 59 subjects had repeated sputum cultures positive for NTM, including both pathogenic NTM as well as nonpathogenic Mycobacterium gordonae. 28 Presumably, the establishment of these infections into a chronic state is due largely to failure of the mucociliary apparatus to clear the organisms, with a subsequent vicious cycle of secondary inflammation, worsening bronchiectasis, and impaired ability to clear infected airway secretions.…”

Section: Prior Bronchiectasismentioning

confidence: 99%

Underlying Host Risk Factors for Nontuberculous Mycobacterial Lung Disease

Chan

Iseman

2013

Semin Respir Crit Care Med

124

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Nontuberculous mycobacteria (NTM) are environmental microbes that cause a variety of human diseases, particularly chronic lung infections. Despite the fact that NTM are widespread in the environment, relatively few people develop NTM lung disease, suggesting intrinsic vulnerability in some individuals. This paper reviews the evidence that underlying disorders predispose to NTM lung disease, in particular primary conditions that result in bronchiectasis, chronic obstructive pulmonary disease, α-1-antitrypsin anomalies, pneumoconiosis, pulmonary alveolar proteinosis, and frank immunosuppressive states such as that associated with the use of anti-tumor necrosis factor-α biologics, posttransplantation immunosuppression, and HIV infection. Over the past several decades, NTM lung disease has been increasingly identified in postmenopausal women with slender body habitus. Thus we will also review the clinical and experimental evidence which supports the observation that such individuals are predisposed to NTM lung disease.

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“…Oboleli od PCD pokazuju odlozenu osetljivost na saharin (>60 min u poredenju sa 10-20 minuta kod zdravih osoba) kada se on plasira na prednju i zadnju nosnu pregradu [8]. Oboleli od PCD pokazuju odlozenu osetljivost na saharin (>60 min u poredenju sa 10-20 minuta kod zdravih osoba) kada se on plasira na prednju i zadnju nosnu pregradu [8].…”

Section: Uvodunclassified