A mild, simple, and efficient approach to the synthesis of some novel 7-benzylidene-2,3-diphenyl-3,3a,4,5,6,7-hexahydro-2H-indazole derivatives

Mahdavinia, Gholam Hossein; Mirzazadeh, Maryam; Karimi-Jaber, Zahed

doi:10.1080/17518253.2014.976280

Green Chemistry Letters and Reviews

2014

DOI: 10.1080/17518253.2014.976280

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A mild, simple, and efficient approach to the synthesis of some novel 7-benzylidene-2,3-diphenyl-3,3a,4,5,6,7-hexahydro-2H-indazole derivatives

Gholam Hossein Mahdavinia

Maryam Mirzazadeh

Zahed Karimi-Jaber

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2020

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An Operationally Simple and Efficient Synthesis of 7-Benzylidene-substitutedphenyl- 3,3a,4,5,6,7-hexahydro-2H-indazole by Grinding Method

Raut¹,

Dhotre

Tidke³

et al. 2020

COS

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Background: An eco-friendly, operationally simple and efficient reaction is shown between various 2,6-bis- (substituted-benzylidene)-cyclohexanone and different substituted hydrazine in presence of acetic acid. Methods: The reaction between various 2,6-bis-(substituted-benzylidene)-cyclohexanone and different substituted hydrazine in presence of acetic acid afford 7-Benzylidene-substituted-phenyl3,3a,4,5,6,7-hexahydro-2H-indazole in 74 to 92 % yield in short reaction time using grindstone technique. Results: Mild synthetic conditions, weak acid catalysis, non-hazardous solvent and environmentally safe are notable advantages of this method Conclusion: In conclusion, we have developed an efficient, simple and eco-friendly method for synthesis of 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7-hexahydro-2H-indazole by grinding technique. The notable benefits of this method are waste minimization, no organic solvent required, simple procedure, easy work-up, clean reaction profile.

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An Operationally Simple and Efficient Synthesis of 7-Benzylidene-substitutedphenyl- 3,3a,4,5,6,7-hexahydro-2H-indazole by Grinding Method

Raut¹,

Dhotre

Tidke³

et al. 2020

COS

View full text Add to dashboard Cite

show abstract

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A mild, simple, and efficient approach to the synthesis of some novel 7-benzylidene-2,3-diphenyl-3,3a,4,5,6,7-hexahydro-2H-indazole derivatives

Cited by 1 publication

References 16 publications

An Operationally Simple and Efficient Synthesis of 7-Benzylidene-substitutedphenyl- 3,3a,4,5,6,7-hexahydro-2H-indazole by Grinding Method

An Operationally Simple and Efficient Synthesis of 7-Benzylidene-substitutedphenyl- 3,3a,4,5,6,7-hexahydro-2H-indazole by Grinding Method

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