A Mini-review on the Phytochemistry and Pharmacobiology of Azadirachta indica A. Juss. (Meliaceae): Towards future research directions

Abstract

Medicinal plants are suppliers of molecules used in both modern and traditional therapy. One of these plants is Azadirachta Indica (also known as the neem tree).Originally from Asia (India), this plant is currently widespread and cultivated in several countries in the world, including in Africa, because of its extraordinary therapeutic properties. A survey carried out on the Internet revealed that A. indica contains various secondary metabolites such as: Azadirone, Nimocimol, Azadiradione, Epoxyazadiradione, nimbinin, salannin, nimbanal, salannol acetate, nimbandiol, tannins, saponins, cardiac glycosides, steroids, gedunin, nimbinene, nimbolide, mahmoodin, margolonone, isomargolonone, azadirachtin, epicatechin, catechin, phenols, alkaloids, flavonoids, steroids, triterpenoids, anthraquinone, anthocyanins. The main structures of these different molecules were drawn using the ChemBioDraw Ultra 12.0 software package. As a result, it has been demonstrated that these compounds confer several pharmacological properties on the neem tree, including anticancer, antifungal, antidiabetic, antibacterial, antiviral, antiplasmodial, and anthelmintic activities. Because of its high anthocyanin content, A. indica could be an interesting candidate for the development of an anti-sickle cell drug.

A mini-review on ethnomedical uses, chemical constituents, pharmacological activities and toxicological study of Alchornea cordifolia (Schum & Thonn) Muell. Arg

“…[1][2][3] Because of their relatively easy accessibility and cheapness, medicinal plants are very important for populations in developing countries. 4,5 Several research and publications highlight that populations in developing countries are increasingly using medicinal plants for their health care. 6,7 Thus, it is notable that plants are a significant source of molecules used not only in traditional medicine, but also in modern medicine around the world.…”