A Minimally Invasive System for Glucose Area Under the Curve Measurement Using Interstitial Fluid Extraction Technology: Evaluation of the Accuracy and Usefulness with Oral Glucose Tolerance Tests in Subjects With and Without Diabetes

Sakaguchi, Kazuhiko; Hirota, Yushi; Hashimoto, Naoko; Ogawa, Wataru; Sato, Toshiyuki; Okada, Seiki; Hagino, Kei; Asakura, Yoshihiro; Kikkawa, Yasuo; Kojima, Junko; Maekawa, Yasunori; Nakajima, Hitoshi

doi:10.1089/dia.2011.0255

Cited by 33 publications

(46 citation statements)

References 22 publications

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“…In accordance with a previous study, 15 good correlation was confirmed between peak PG levels and IG AUC or PG AUC (R = 0.87 for IG AUC and R = 0.96 for PG AUC in Figures 5A and 5B), suggesting that peak glucose levels can be detected simply and precisely by MIET without blood sampling. The strong correlation between IG AUC and PG levels at 1 h (R = 0.86) indicated that the time of peak PG level occurred mostly at 1 h after glucose loading (Figure 5C), explaining the weaker correlation between IG AUC and PG levels at 2 h (R = 0.82; Figure 5D).…”

Section: Correlation Between Interstitial Fluid Glucose Area Under Thsupporting

confidence: 92%

Evaluation of a Minimally Invasive System for Measuring Glucose Area under the Curve during Oral Glucose Tolerance Tests: Usefulness of Sweat Monitoring for Precise Measurement

Sakaguchi

Hirota

Hashimoto

et al. 2013

J Diabetes Sci Technol

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Abbreviations: (ADA) American Diabetes Association, (AUC) area under the curve, (CGM) continuous glucose monitoring, (DM) diabetes mellitus, (FPG) fasting plasma glucose, (IDF) International Diabetes Federation, (IG) interstitial fluid glucose, (IRI) immunoreactive insulin, (ISF) interstitial fluid, (MIET) minimally invasive interstitial fluid extraction technology, (OGTT) oral glucose tolerance test, (PG) plasma glucose, (SMBG) selfmonitoring of blood glucose

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Section: Correlation Between Interstitial Fluid Glucose Area Under Thsupporting

confidence: 92%

Evaluation of a Minimally Invasive System for Measuring Glucose Area under the Curve during Oral Glucose Tolerance Tests: Usefulness of Sweat Monitoring for Precise Measurement

Sakaguchi

Hirota

Hashimoto

et al. 2013

J Diabetes Sci Technol

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“…Microneedles are used for extraction of interstitial fluid prior to ex-vivo measurement. [20][21][22] El-Laboudi et al have outlined the state-of-the-art in the use of microneedles as biosensors for glucose monitoring. 19 Interest in mHealth (mobile health) apps and devices is soaring, generating a huge social appetite and financial market for wearable sensors.…”

Section: Evolution Of Microneedle Biosensorsmentioning

confidence: 99%

Toward Biofunctional Microneedles for Stimulus Responsive Drug Delivery

Cahill

O’Cearbhaill

2015

Bioconjugate Chem.

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Microneedles have recently been adopted for use as a painless and safe method of transdermal therapeutic delivery through physically permeating the stratum corneum. While microneedles create pathways to introduce drugs, they can also act as conduits for biosignal sensing. Here, we explore the development of microneedles as both biosensing and drug delivery platforms. Microneedle sensors are being developed for continuous monitoring of biopotentials and bioanalytes through the use of conductive and electrochemically reactive biomaterials. The range of therapeutics being delivered through microneedle devices has diversified, while novel bioabsorbable microneedles are undergoing first-in-human clinical studies. We foresee that future microneedle platform development will focus on the incorporation of biofunctional materials, designed to deliver therapeutics in a stimulus responsive fashion. Biofunctional microneedle patches will require improved methods of attaching to and conforming to epithelial tissues in dynamic environments for longer periods of time and thus present an assortment of new design challenges. Through the evolution of biomaterial development and microneedle design, biofunctional microneedles are proposed as a next generation of stimulus responsive drug delivery systems.

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“…Systems containing microneedle arrays have previously been developed for sampling of analytes in transdermal blood and/or interstitial fluid [18][19][20] . For instance, systems containing microneedles arrays have been developed for detection of glutamate [21] , glucose [22,23] , and potassium ions [24] . In this study, microneedle arrays were used as a sampling mechanism for detection of histamine in fish flesh.…”

Section: Introductionmentioning

confidence: 99%

Microstereolithography-fabricated microneedles for fluid sampling of histamine-contaminated tuna

Boehm¹,

Jaipan

Yang

et al. 2024

IJB

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Abstract:A custom-designed microneedle sampling system was prepared using dynamic mask microstereolithography; this sampling system was used for determination of histamine content in fresh, histamine-spiked, and spoiled tuna flesh. Lateral flow (test strip) assays were successfully utilized in the microneedle sampling system to assess histamine content. Good agreement was noted between data obtained from the microneedle sampling system and a commercially available histamine detection kit. A discrepancy was noted in the results from the microneedle sampling system and the commercially available histamine detection kit at low (negative) levels of histamine. There was an improvement in the agreement between the microneedle sampling system and the commercially available histamine detection kit at higher histamine levels. The results, which showed an improvement in the test duration and the amount of reagent needed for histamine detection, indicate the promise of printed microneedle sampling systems for histamine detection in seafood samples and other types of food testing.

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A Minimally Invasive System for Glucose Area Under the Curve Measurement Using Interstitial Fluid Extraction Technology: Evaluation of the Accuracy and Usefulness with Oral Glucose Tolerance Tests in Subjects With and Without Diabetes

Abstract: The glucose AUC monitoring system using IG provided good estimates of reference PG-AUC and maximum PG level during OGTTs in subjects with and without diabetes. This system provides easy-to-use monitoring of glucose AUC, which is a good indicator of postprandial glucose.

Cited by 33 publications

References 22 publications

Evaluation of a Minimally Invasive System for Measuring Glucose Area under the Curve during Oral Glucose Tolerance Tests: Usefulness of Sweat Monitoring for Precise Measurement

Evaluation of a Minimally Invasive System for Measuring Glucose Area under the Curve during Oral Glucose Tolerance Tests: Usefulness of Sweat Monitoring for Precise Measurement

Toward Biofunctional Microneedles for Stimulus Responsive Drug Delivery

Microstereolithography-fabricated microneedles for fluid sampling of histamine-contaminated tuna

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