A minireview on what we have learned about urease inhibitors of agricultural interest since mid-2000s

Modolo, Luzia V.; da-Silva, Cristiane Jovelina; Brandão, Débora; Chaves, Izabel S.

doi:10.1016/j.jare.2018.04.001

Cited by 124 publications

(69 citation statements)

References 56 publications

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“…1,4 and covalent modification. Currently, the group of urease inhibitors has been expanded to include hydroquinone, derivatives of coumarin, phenolic aldehydes and catechol [116]. Catechol inactivates the urease metallocentre by the formation of catechol-metal complexes.…”

Section: Soil Enzymementioning

confidence: 99%

Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

Zaborowska

Wyszkowska

Borowik

2020

IJMS

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The choice of the study objective was affected by numerous controversies and concerns around bisphenol F (BPF) and bisphenol S (BPS)—analogues of bisphenol A (BPA). The study focused on the determination and comparison of the scale of the BPA, BPF, and BPS impact on the soil microbiome and its enzymatic activity. The following parameters were determined in soil uncontaminated and contaminated with BPA, BPF, and BPS: the count of eleven groups of microorganisms, colony development (CD) index, microorganism ecophysiological diversity (EP) index, genetic diversity of bacteria and activity of dehydrogenases (Deh), urease (Ure), catalase (Cat), acid phosphatase (Pac), alkaline phosphatase (Pal), arylsulphatase (Aryl) and β-glucosidase (Glu). Bisphenols A, S and F significantly disrupted the soil homeostasis. BPF is regarded as the most toxic, followed by BPS and BPA. BPF and BPS reduced the abundance of Proteobacteria and Acidobacteria and increased that of Actinobacteria. Unique types of bacteria were identified as well as the characteristics of each bisphenol: Lysobacter, Steroidobacter, Variovorax, Mycoplana, for BPA, Caldilinea, Arthrobacter, Cellulosimicrobium and Promicromonospora for BPF and Dactylosporangium Geodermatophilus, Sphingopyxis for BPS. Considering the strength of a negative impact of bisphenols on the soil biochemical activity, they can be arranged as follows: BPS > BPF > BPA. Urease and arylsulphatase proved to be the most susceptible and dehydrogenases the least susceptible to bisphenols pressure, regardless of the study duration.

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Section: Soil Enzymementioning

confidence: 99%

Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

Zaborowska

Wyszkowska

Borowik

2020

IJMS

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“…Since the 1960s, the global use of N fertilizers has grown nearly seven-fold [10,11], but the overall yield increase was only 2.4-fold [12,13]. Worldwide, more than 50% to 75% of applied N fertilizer is not taken up by crops [14][15][16], and recovery of applied N by maize (Zea mays L.) rarely exceeds 50% [17,18]. Nitrogen use efficiency (NUE) can be defined as the increase in grain yield per unit of applied N and is the product of absorption efficiency (increase in absorbed N per unit of applied N) and utilization efficiency (increase in grain yield per unit of absorbed N) [19,20].…”

Section: Nitrogen Application In Crop Productionmentioning

confidence: 99%

Mechanisms of Nitrogen Use in Maize

2019

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Nitrogen (N) fertilizers are needed to enhance maize (Zea mays L.) production. Maize plays a major role in the livestock industry, biofuels, and human nutrition. Globally, less than one-half of applied N is recovered by maize. Although the application of N fertilizer can improve maize yield, excess N application due to low knowledge of the mechanisms of nitrogen use efficiency (NUE) poses serious threats to environmental sustainability. Increased environmental consciousness and an ever-increasing human population necessitate improved N utilization strategies in maize production. Enhanced understanding of the relationship between maize growth and productivity and the dynamics of maize N recovery are of major significance. A better understanding of the metabolic and genetic control of N acquisition and remobilization during vegetative and reproductive phases are important to improve maize productivity and to avoid excessive use of N fertilizers. Synchronizing the N supply with maize N demand throughout the growing season is key to improving NUE and reducing N loss to the environment. This review examines the mechanisms of N use in maize to provide a basis for driving innovations to improve NUE and reduce risks of negative environmental impacts.

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“…During the last two decades, a large array of metals and organic substances have been found to inhibit urease. Amongst synthetic organic compounds, the most actives include phosphoramidates, thioureas, dimeric vanadium complexes, benzothiazoles, coumarinyl pyrazolinyl thioamides and dihydropyrimidin(thi)one . Several classes of plant‐derived compounds, including terpenoids, phenolic acids, flavonoids, stilbenes, xanthones, coumarins alkaloids and quinones, among others, have preceding last years, special attention has focused on quinones due to their wide array of biological properties, specially antiureolytic activity .…”

Section: Introductionmentioning

confidence: 99%

Antiureolytic Activity of Substituted 2,5‐Diaminobenzoquinones

Nain-Pérez

Barbosa

Rodríguez-Hernández

et al. 2019

Chemistry & Biodiversity

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A series of 2,5-bis(alkyl/arylamino)-1,4-benzoquinones (1-12) were investigated in vitro for their potential to inhibit the activity of jack bean urease. Compounds 1 -6, 8, 9, 11 and 12 effectively inhibited the jack bean urease activity by 90.8 % when tested at 5 μM, whereas 7 and 10 had relatively little effect. The IC 50 for most compounds was in the nanomolar range (31.4 nM and 36.0 nM for 2 and 8, respectively). The mechanism of enzyme inhibition shown by 2 and 8 is typical of mixed-type inhibitors, whose affinity for the active site is over 6-and 2-fold higher (K i = 30.0 and 22.8 nM, for 2 and 8, respectively) than that of an allosteric site. Molecular docking studies revealed that both 2 and 8 establish hydrogen bonds with the amino acids residues Asp494, Met588, His593 and Ala636 in the active site of jack bean urease. These results indicate that such aminoquinones are useful leads for the development of more efficient urease inhibitors of wider utility. Scheme 1. Structures of 2,5-bis(alky/arylamino)-1,4-benzoquinones used in this study.

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A minireview on what we have learned about urease inhibitors of agricultural interest since mid-2000s

Abstract: Graphical abstract

Cited by 124 publications

References 56 publications

Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

Mechanisms of Nitrogen Use in Maize

Antiureolytic Activity of Substituted 2,5‐Diaminobenzoquinones

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