“…Principles from the Dow's re and explosion index guide (American Institute of Chemical Engineers, 1994) were incorporated into an MILP model by Patsiatzis et al (2004) in estimating risk levels within a plant, and more recently, the Domino Hazard index has also been adopted to model potential hazardous events that can be mitigated with proper layout considerations (Brunoro Ahumada et al, 2018, de Lira-Flores et al, 2014, López-Molina et al, 2013, Tugnoli et al, 2008. In the later case, the domino eect of hazardous scenarios such as ash re, reball, pool and jet res, and explosions were formulated as an MINLP (López-Molina et al, 2013, de Lira-Flores et al, 2014 or MILP (Brunoro Ahumada et al, 2018) model, with an overall objective to minimize the total layout costs, damage costs and purchase of protection devices. In recent times, owing to problems of scalability, heuristics, the use of evolutionary techniques and the combination of both have been developed for the layout problem.…”