“…From an optimisation point of view, safety factors in layout designs have been considered in the past. A great deal of research have focused on the economic aspects -piping, construction and operational costs -associated with a layout conguration in single and multi-oor scenarios (Barbosa-Póvoa et al, 2002, Ejeh et al, 2018a2019b, Georgiadis and Macchietto, 1997, Guirardello and Swaney, 2005, Hwang and Lee, 2014, Papageorgiou and Rotstein, 1998, Park et al, 20112018, Patsiatzis andPapageorgiou, 2002;2003). However, an ideal plant layout design ought to establish a balance between risks and cost savings.…”