A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1

Xu, Youqin; Ji, Kaiyuan; Wu, Meng; Hao, Bingtao; Yao, Kangde; Xu, Yang

doi:10.1007/s13238-019-0607-2

Cited by 20 publications

(20 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many pathological conditions are caused by the imbalance of miRNAs [ 4 – 6 ], including neurodegenerative diseases, inflammatory diseases, metabolic diseases [ 7 ], cardiovascular diseases, and cancer [ 8 , 9 ]. Changes in microRNA expression are closely related to the occurrence, invasion, metastasis, and drug resistance of cancer cells [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Study on the Correlation between miRNA-373 and HIF-1α, MMP-9, and VEGF in the Development of HIE

Liu

Al-Ward

Mekontso

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Introduction. Microribonucleic acids (miRNAs) have short (approximately 18 to 25) nucleotides and are evolutionarily conserved and endogenously expressed RNAs belonging to a family of noncoding RNA molecules. miRNA-373 regulates cell proliferation, migration, apoptosis, invasion, and repairing damaged DNA after hypoxia stress. Neonatal hypoxic–ischemic encephalopathy (HIE) refers to perinatal asphyxia caused by partial or complete hypoxia, reduced or suspended cerebral blood flow, and fetal or neonatal brain damage. We aim to investigate the relationship between miRNA-373 and HIF-1α, between miRNA-373 MMP-9, and between miRNA-373 VEGF in the occurrence and development of HIE. Methods. Human (children) samples were divided into four groups ( n = 15 in each group) according to HIE severity. The patient group was divided into middle, moderate, and severe HIE groups. The control group included healthy children or children with nonneurological diseases. The expressions of miRNA-373, HIF-1α, MMP-9, and VEGF were assayed in the serum samples. Results. Our study showed a strong relationship between miRNA-373 and HIF-1α, between miRNA-373 and MMP-9, and between miRNA-373 and VEGF. The expression levels of miRNA-373, HIF-1α, MMP-9, and VEGF in the HIE groups were much higher than those of the control group. Conclusion. The increased change in miRNA-373 expression has a certain diagnostic significance on neonatal HIE. In the occurrence and development of HIE, miRNA-373 is positively correlated with HIF-1α, MMP-9, and VEGF.

show abstract

Section: Introductionmentioning

confidence: 99%

Experimental Study on the Correlation between miRNA-373 and HIF-1α, MMP-9, and VEGF in the Development of HIE

Liu

Al-Ward

Mekontso

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…High expression of HERC4 is associated with poor prognosis in patients with IBC 47 . The silence of EPHX2 could induce apoptosis in prostate cancer cells by reducing androgen receptor signalling 48 . C6orf141 could be silenced by ZNF217 overexpression, thereby promoting BC cell metastasis to bones 49,50 .…”

Section: Discussionmentioning

confidence: 99%

Transcriptome-wide analysis and modelling of prognostic alternative splicing signatures in invasive breast cancer: a prospective clinical study

Wang

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Aberrant alternative splicing (AS) has been highly involved in the tumorigenesis and progression of most cancers. The potential role of AS in invasive breast cancer (IBC) remains largely unknown. In this study, RNA sequencing of IBC samples from The Cancer Genome Atlas was acquired. AS events were screened by conducting univariate and multivariate Cox analysis and least absolute shrinkage and selection operator regression. In total, 2146 survival-related AS events were identified from 1551 parental genes, of which 93 were related to prognosis, and a prognostic marker model containing 14 AS events was constructed. We also constructed the regulatory network of splicing factors (SFs) and AS events, and identified DDX39B as the node SF gene, and verified the accuracy of the network through experiments. Next, we performed quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) in triple negative breast cancer patients with different responses to neoadjuvant chemotherapy, and found that the exon-specific expression of EPHX2, C6orf141, and HERC4 was associated with the different status of patients that received neoadjuvant chemotherapy. In conclusion, this study found that DDX39B, EPHX2 (exo7), and HERC4 (exo23) can be used as potential targets for the treatment of breast cancer, which provides a new idea for the treatment of breast cancer.

show abstract

“…It is a common to study the biological processes including physiological processes, disease pathogenesis and progression, and pharmacological research of pharmacological treatment and drug resistance by focusing on the key genetic events (copy number variations (Pan et al, 2020 ), mutations (Zheng et al, 2019 , etc. ), genes (Zhou 2020 ), RNAs (miRNAs Xu et al ( 2019 ), lncRNAs (Lin et al, 2019 , etc. ), proteins Shao et al ( 2016 ), signaling pathways (Liao et al, 2018 ), or key cells (Mittal et al, 2019 ), etc.…”

Section: Current Applicationsmentioning

confidence: 99%

New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data

et al. 2020

View full text Add to dashboard Cite

For multicellular organisms, cell-cell communication is essential to numerous biological processes. Drawing upon the latest development of single-cell RNA-sequencing (scRNA-seq), high-resolution transcriptomic data have deepened our understanding of cellular phenotype heterogeneity and composition of complex tissues, which enables systematic cell-cell communication studies at a single-cell level. We first summarize a common workflow of cell-cell communication study using scRNA-seq data, which often includes data preparation, construction of communication networks, and result validation. Two common strategies taken to uncover cell-cell communications are reviewed, e.g., physically vicinal structure-based and ligand-receptor interaction-based one. To conclude, challenges and current applications of cell-cell communication studies at a single-cell resolution are discussed in details and future perspectives are proposed.

show abstract

A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1

Cited by 20 publications

References 34 publications

Experimental Study on the Correlation between miRNA-373 and HIF-1α, MMP-9, and VEGF in the Development of HIE

Experimental Study on the Correlation between miRNA-373 and HIF-1α, MMP-9, and VEGF in the Development of HIE

Transcriptome-wide analysis and modelling of prognostic alternative splicing signatures in invasive breast cancer: a prospective clinical study

New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data

Contact Info

Product

Resources

About