A mitochondria-targeted single fluorescence probe for separately and continuously visualizing H2S and Cys with multi-response signals

Zhao, Xinxin; Ji, Hefang; Hasrat, Kamran; Misal, Saima; He, Fangru; Dai, Yanpeng; Ma, Fulong; Qi, Zhengjian

doi:10.1016/j.aca.2020.02.017

Cited by 33 publications

(10 citation statements)

References 55 publications

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“…More significantly, BH 990 and BH 1024 exhibited relative small Δ E S1→T1 (0.3661, 0.3774 eV), which was very favoring high ISC efficiency. [ 50 ] Advantageously again, besides the ISC from S 1 to T 1 , the nearly isoenergetic S 1 and T 2 levels of BH 990 and BH 1024 revealed another feasibility of efficient ISC path from S 1 to T 2 . Collectively, theoretical calculation results positively predicted that BH 990 and BH 1024 held great potential for NIR‐II light‐triggered oxygen sensitization, thanks to the strong NIR‐II absorption and enough triplet energy levels.…”

Section: Resultsmentioning

confidence: 99%

Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep‐Seated Tumors

Bian

Zhang

et al. 2021

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Small molecular dye that simultaneously exerts dual PDT/PTT effects as well as florescence imaging triggered by a single NIR‐II light has never been reported to date. Apart from the huge challenge in pushing absorption profile into NIR‐II region, fine‐tuning dyes’ excited state via rational structure design to meet all three functions, especially oxygen photosensitization, remains the most prominent throttle. Herein, five novel NIR‐II dyes (BHs) are productively developed by strategically conjugating dyad innovative xanthonium with sequentially extended polymethine bridges, enabling intense absorption from 890 to 1206 nm, significantly 400 nm longer than conventional cyanine dyes with same polymethines. More importantly, owning to high resonance and favorable excited state energy population induced by greater rigidity via ring‐fused amino, BH 1024 exhibits best singlet oxygen generation capability, moderate photothermal heating, and considerable fluorescence under 1064 nm laser irradiation. Furthermore, BH 1024 is encapsulated into folate‐functionalized polymer, which demonstrated a synergetic PDT/PTT effect in vitro and in vivo, eventually achieving solid tumors elimination under NIR‐II fluorescence guide. As far as it is known, this is the first time small molecular dyes for NIR‐II PDT or NIR‐II PDT/PTT are explored and designed.

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Section: Resultsmentioning

confidence: 99%

Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep‐Seated Tumors

Bian

Zhang

et al. 2021

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128

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“…It has been proven that the abnormalities of the tumor might have a synergic effect when they coexist, which leads to more severe effects if they happened individually. Therefore, developing dual-target triggered RNPs might shed more light on the correlations between these hallmarks in the microenvironment of chronic diseases in order to gain more information about their progression and come up with better solutions to efficiently treat them. ,− …”

Section: Minimizing Falsified Signals Generated By Rnpsmentioning

confidence: 99%

Vision for Ratiometric Nanoprobes: In Vivo Noninvasive Visualization and Readout of Physiological Hallmarks

et al. 2023

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Lesion areas are distinguished from normal tissues surrounding them by distinct physiological characteristics. These features serve as biological hallmarks with which targeted biomedical imaging of the lesion sites can be achieved. Although tremendous efforts have been devoted to providing smart imaging probes with the capability of visualizing the physiological hallmarks at the molecular level, the majority of them are merely able to derive anatomical information from the tissues of interest, and thus are not suitable for taking part in in vivo quantification of the biomarkers. Recent advances in chemical construction of advanced ratiometric nanoprobes (RNPs) have enabled a horizon for quantitatively monitoring the biological abnormalities in vivo. In contrast to the conventional probes whose dependency of output on single-signal profiles restricts them from taking part in quantitative practices, RNPs are designed to provide information in two channels, affording a self-calibration opportunity to exclude the analyte-independent factors from the outputs and address the issue. Most of the conventional RNPs have encountered several challenges regarding the reliability and sufficiency of the obtained data for high-performance imaging. In this Review, we have summarized the recent progresses in developing highly advanced RNPs with the capabilities of deriving maximized information from the lesion areas of interest as well as adapting themselves to the complex biological systems in order to minimize microenvironmental-induced falsified signals. To provide a better outlook on the current advanced RNPs, nanoprobes based on optical, photoacoustic, and magnetic resonance imaging modalities for visualizing a wide range of analytes such as pH, reactive species, and different derivations of amino acids have been included. Furthermore, the physicochemical properties of the RNPs, the major constituents of the nanosystems and the analyte recognition mechanisms have been introduced. Moreover, the alterations in the values of the ratiometric signal in response to the analyte of interest as well as the time at which the highest value is achieved, have been included for most of RNPs discussed in this Review. Finally, the challenges as well as future perspectives in the field are discussed.

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“…Multi‐response fluorescent probes can simultaneously or sequentially recognize two or more biological molecules and play a significant role in H 2 S detection. During the past five years, multi‐response fluorescent probes have been widely applied in disease diagnoses and physiological and pathological processes visualization by fluorescence imaging in vitro and in vivo [68,73,75,83] . Although significant progress has been made in multi‐response fluorescent probes, a fluorescent probe that can simultaneously distinguish more than one analyte remains a huge challenge: (1) the design of multi‐response fluorescent probes; (2) slow response to the analyte; (3) mutual interference of multiple fluorescent emission.…”

Section: Classification Of Fluorescent H2s Probesmentioning

confidence: 99%

“…During the past five years, multi-response fluorescent probes have been widely applied in disease diagnoses and physiological and pathological processes visualization by fluorescence imaging in vitro and in vivo. [68,73,75,83] Although significant progress has been made in multi-response fluorescent probes, a fluorescent probe that can simultaneously distinguish more than one analyte remains a huge challenge: (1) the design of multi-response In 2021, Zhou et al developed a new turn-on fluorescent probe that can simultaneously recognize three different types of thiols (Cys/Hcy/H 2 S, GSH, and SO 2 ) from each other by different signals: red and green for Cys/Hcy/H 2 S, red for GSH, and green for SO 2 (Figure 6). [84] However, the signal channels between Cys/Hcy/H 2 S, GSH, and SO 2 are overlapped to a certain extent, which may cause inter-species interference.…”

Section: Multi-response Fluorescent Probesmentioning

confidence: 99%

Fluorescent Probes for Sensing and Imaging Biological Hydrogen Sulfide

2022

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Hydrogen sulfide (H2S) is an important endogenous biological signal molecule that plays an essential role in various pathological and physiological processes. Abnormal expression of H2S in vivo is associated with the occurrence and development of many diseases. Therefore, sensing biological H2S level and distribution is significant and has been extensively studied presently. A few reviews about H2S sensing and imaging have been reported, most of which focus on the sensing mechanisms and construction of probes. In this review, we firstly summarized and classified the H2S‐activated fluorescent probes over the past 5 years according to sensing modality and then mainly discussed their biological applications, including detection of physiological and pathological processes, diagnosis of diseases, and disease treatments. It is expected that this review can deepen the readers′ understanding of the biological role of H2S and provide them with biomedical background knowledge for the construction of the H2S probes.

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A mitochondria-targeted single fluorescence probe for separately and continuously visualizing H2S and Cys with multi-response signals

Cited by 33 publications

References 55 publications

Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep‐Seated Tumors

Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep‐Seated Tumors

Vision for Ratiometric Nanoprobes: In Vivo Noninvasive Visualization and Readout of Physiological Hallmarks

Fluorescent Probes for Sensing and Imaging Biological Hydrogen Sulfide

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