A mixture of the aqueous extract of Garcinia cambogia, soy peptide and l-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet

Abstract

The aim of the present study was to investigate the anti-obesity effect of a mixture composed of Garcinia cambogia extract, soypeptide, and L: -carnitine (1.2:0.3:0.02, w/w/w) in rats rendered obese by a high-fat diet (HFD). Sprague-Dawley rats were fed either the high-fat control diet (CD) or the 0.38% mixture-supplemented HFD (CD + M) for 9 weeks. The mixture significantly reduced body weight gain and the accumulation of visceral fat mass in a rat model of HFD-induced obesity. Moreover, the mixture effectively lowered blood and hepatic lipid concentrations and serum glucose, insulin, c-peptide, and leptin levels in rats with HFD-induced obesity. Results from real-time reverse transcription-polymerase chain reaction analyses indicated that the expression levels of leptin, tumor necrosis factor-alpha (TNF-alpha), and sterol regulatory element binding protein 1c (SREBP1c) genes in the epididymal fat tissue of rats fed the CD + M diet were 0.4-, 0.6-, and 0.48-fold, respectively, of those found in the CD rats (P < 0.05), while expression of the uncoupling protein 2 (UCP2) gene in epididymal adipose tissue was 1.25-fold (P < 0.05) of that found in CD rats. In conclusion, a mixture composed of G. cambogia extract, soy peptide, and L: -carnitine attenuated visceral fat accumulation and improved dyslipidemia in a rat model with HFD-induced obesity.

<i>Garcinia Cambogia</i> Extracts Prevented Fat Accumulation via Adiponectin-AMPK Signaling Pathway in Developing Obesity Rats

“…The body weight gain, Lee's index, relative weight of epididymal fat, and triglyceride concentrations in serum and hepatic were significantly decreased in dietary supplementation of Garcinia Cambogia extracts to rats under fed high-fat diet. This observation concurs with the finding of Kim et al (Kim et al, 2007), who reported that Garcinia Cambogia extracts could reduce the accumulation of visceral fat mass and triglyceride content in rats rendered obese by a high fat diet. As a weight loss agent, many studies had reported that (-)-HCA, the principal acid and the major active ingredient of Garcinia Cambogia extracts, safely promote weight loss in laboratory animals (Kang et al, 2007;Kim et al 2004) and humans (Kim et al, 2011;Márquez, 2012), and suggested food intake regulation may be a major mechanism of weight loss by Garcinia Cambogia extracts-induced (Louter-van de Haar et al, 2005).…”

“…Cambogia extracts treatment and obesity control and other metabolic effects, such as inhibiting fat accumulation and dyslipidemia (Kim et al, 2007;Roy et al, 2003;Roy et al, 2007;Saito et al, 2005). In the present study, we investigated the antiobesity effect of Garcinia Cambogia extracts in rats under fed high-fat diet and the possible mechanism of this action.…”

“…In addition to exercise, it is well known that anti-obesity foods and food ingredients could control and reduce body weight. Some herbal products and plant extracts, such as Semen Cassiaem (Junbao et al, 2004), Panax ginseng berry extract (Attele et al, 2002), Singiber officinale Roscoe (Hasegawa, 2001), and Platycodi radix (Han et al, 2000) have been shown to exert anti-obesity effects in rodents with high fat diet induced obesity (Kim et al, 2007).…”

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

“…Diet-induced obesity (DIO) models have been well established, and widely used to find effective functional foods for anti-obesity. In recent studies, many observations have been reported concerning the ingestion of certain functional foods or their components decreasing the accumulation of body fat and inhibiting the elevation of body weight (23)(24)(25)(26)(27).…”

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

“…Citrate is an allosteric regulator for a number of enzymes that are involved in carbohydrate and fat metabolism, such as phosphofructokinase (the enzyme regulating glycolysis) [33] and acetyl-CoA carboxylase (the enzyme regulating fatty acid synthesis) [34]. It had been reported that (-)-HCA has a much greater affinity to the citrate lyase than that to citrate [22, 35]. Thus, (-)-HCA supplementation is expected to alter metabolic pathways.…”