A MLH1 polymorphism that increases cancer risk is associated with better outcome in sporadic colorectal cancer

Nejda, Nargisse; Iglesias, Daniel; Azcoita, M Moreno; Arana, Vicente Medina; González-Aguilera, Juan J.; Fernández-Peralta, Antonia M.

doi:10.1016/j.cancergencyto.2009.04.011

Cited by 26 publications

(20 citation statements)

References 35 publications

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“…Actually, the 655G allele appears to confer a 2-fold increased risk to develop CRC in Mexican patients, a finding similar to that observed in 140 Spanish patients with sporadic CRC (Nejda et al, 2009). According to immunohistochemical analysis, it has been suggested that this polymorphism correlates with protein expression (Kim et al, 2004).…”

Section: Discussionsupporting

confidence: 65%

MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer

Muñiz-Mendoza¹,

Ml²,

Partida-Pérez³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral blood of 108 individuals with CRC (study group) at diagnosis and 120 blood donors (control group) from Western Mexico; both groups ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (3): 2315-2320 (2012) R. Muñiz-Mendoza et al. 2316 were mestizos. The polymorphisms were detected by PCR-RFLP. Association was estimated by calculating the odds ratio (OR). We found that the MLH1 and XRCC1 polymorphisms were in HardyWeinberg equilibrium. The MLH1 655A>G polymorphism in the 655G allele was associated with a 2-fold increase risk for CRC (OR = 2.04 and 95% confidence interval (95%CI) = 1.12-3.69; P < 0.01), while the MLH1 -93G>A polymorphism allele was associated with a protective effect (OR = 0.60, 95%CI = 0.40-0.89; P = 0.01 in the -93A allele and OR = 0.32, 95%CI = 0.13-0.79; P = 0.01 in the AA genotype). The XRCC1 Arg194Trp and Arg399Gln polymorphisms did not show any significant associations. In conclusion, we found that MLH1 -93G>A and 655A>G polymorphisms are associated with CRC in Mexican patients.

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Section: Discussionsupporting

confidence: 65%

MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer

Muñiz-Mendoza¹,

Ml²,

Partida-Pérez³

et al. 2012

Genet. Mol. Res.

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“…12,13,17 Third, the MLH1 rs1799977 AG/GG genotype harbors prognostic relevance also in disease models other than lymphoma, including acute lymphoblastic leukemia, solid tumors, and inflammatory bowel disease. [40][41][42][43][44][45][46][47] The cross-validation approach of the current study documents that the MLH1 rs1799977 genotype is an independent prognostic factor retaining its value in 2 DLBCL series treated at different institutions using similar therapeutic strategies. This observation suggests that the prognostic value of MLH1, although detected retrospectively, appears to be independent of a potential bias because of patient referral or patient management at a single center.…”

Section: Discussionmentioning

confidence: 99%

The host genetic background of DNA repair mechanisms is an independent predictor of survival in diffuse large B-cell lymphoma

Rossi

Rasi

Rocco

et al. 2011

Blood

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“…Reduced MLH1 protein associated with c.655A>G polymorphism was also documented among sporadic CRCs in Korean population [23]. Many studies reported to occur of MLH1 c.655A>G in association with CRC risk at frequency ≥ 1% [24][25][26]. This variant is not only involved in colorectal cancer, but also in some other types of cancers.…”

Section: Discussionmentioning

confidence: 86%