“…Nevertheless, research finding are mixed with regard to the learning effectiveness of VR-based learning. Positive research outcomes have been reported with VR-based learning such as better performance in business knowledge application (Cheng & Wang, 2011); improved anatomy learning (Petersson, Sinkvist, Wang, & Smedby, 2009); greater efficiency in matching diagrams and models (Stull, Barrett, & Hegarty, 2013); improved calligraphic writing skills (Wu, Yuan, Zhou, & Cai, 2013); improved spatial thinking (Cohen & Hegarty, 2014;Dünser, Steinbügl, Kaufmann, & Glück, 2006;Hauptman, 2010); enhanced spatial abilities for "sensing" and kinesthetic learning style learners (Hauptman & Cohen, 2011) and for low visual spatial ability learners (Meijer & van den Broek, 2010); and the ability to accommodate learners with different learning styles in cognitive outcomes (Chen, Toh, & Wan, 2005;Lee, Wong, & Fung, 2010b) and affective outcomes (Lee et al, 2010b) On the other hand, Urhahne, Nick, and Schanze (2009) found no difference in understanding chemical structures and their properties for freshman students using 3-D simulations and two-dimensional (2-D) images. Similarly, in the study of Merchant, Goetz, Keeney-Kennicutt, Cifuentes, Kwokt, and Davis (2013), the hypothesis that 3-D virtual environment can enhance chemistry learning among undergraduate M A N U S C R I P T…”