Retrofitting an existing building can oftentimes be more cost-effective than building a new facility. Since buildings consume a significant amount of energy, particularly for heating and cooling, and because existing buildings comprise the largest segment of the built environment, it is important to initiate energy conservation retrofits to reduce energy consumption and the cost of heating, cooling, and lighting buildings. However, conserving energy is not the only reason for retrofitting existing buildings. The goal should be to create a high-performance building by applying an integrated, whole-building design process to the project during the planning phase that ensures that all key design objectives are met. This paper presents a real case study of the retrofitting of an existing building to achieve lower energy consumption. Indeed, most of the constructed buildings in the UAE are unsuitable for the region, which is characterized by a very harsh climate that causes massive cooling loads and energy consumption due to an appropriate selection of design parameters at the design level. In this study, a monthly computer simulation of energy consumption of an office building in Sharjah was carried out under UAE weather conditions. Several parameters, including the building orientation, heating, ventilation, and air conditioning (HVAC) system, external shading, window-to-wall ratio, and the U-values of the walls and the roof, were investigated and optimized to achieve lower energy consumption. The simulation shows that the best case is 41.7% more efficient than the real (original) case and 30.6% more than the base case. The most sensitive parameter in the retrofitting alternatives is the roof component, which affects the energy savings by 8.49%, followed by the AC system with 8.34% energy savings if well selected using the base case. Among the selected five components, a new roof structure contributed the most to the decrease in the overall energy consumption (approximately 38%). This is followed by a new HVAC system, which leads to a 37% decrease, followed by a new wall type with insulation, resulting in a 20% decrease.