This study provides new evidence on the relationship between leadership style, job stress, and the intention to leave of employees in supply enterprises in Vietnam in the context of the COVID-19 epidemic. Unlike most previous studies, the results of this study found that the level of work stress of employees is quite high (4.03 points) and is positively affected by the transactional leadership style, while that of transformational leadership style will reduce stress levels. The study also found that, although the level of work stress was high, the intention to quit was quite low; the older the workers, the lower the intention to quit; and women have a higher intention to quit than men. However, this study has many limitations when it does not consider factors affecting work stress and intention to leave other jobs such as job satisfaction, working environment, etc. Research results provide a theoretical and practical basis for leaders at supply enterprises in adjusting human resource management policies to reduce stress for employees and enhance long-term commitment. with the company.