A Model of Glutamate Neurotoxicity and Mechanisms of the Development of the Typical Pathological Process

Реутов, В. П.; Samosudova, N. V.; Sorokina, Elena M.

doi:10.1134/s0006350919020143

Cited by 16 publications

(10 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the second case, irreversible violations occur. Against the background of oxidative and nitrosative stress, a typical pathological process develops [78] with its nonspecific pathological reactions characteristic not only of moderate and severe traumatic brain injury [79]. Such processes are universal in nature and develop during hypoxia/ischemia, moderate neurotoxicity of glutamate [73][74][75]77,78], and also participate in the development of the pathogenesis of neurological diseases and mental disorders [80] with long-term consequences as in patients after brain injuries of mild to moderate severity [79,81], and in patients who have been infected with Covid-19 [80,82].…”

Section: Discussionmentioning

confidence: 99%

Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age

Yang

Hung

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity among the global youth and commonly results in long-lasting sequelae, including paralysis, epilepsy, and a host of mental disorders such as major depressive disorder. Previous studies were mainly focused on severe TBI as it occurs in adults. This study explored the long-term adverse effect of mild TBI in juvenile animals (mTBI-J). Male Sprague Dawley rats received mTBI-J or sham treatment at six weeks old, then underwent behavioral, biochemical, and histological experiments three weeks later (at nine weeks old). TTC staining, H&E staining, and brain edema measurement were applied to evaluate the mTBI-J induced cerebral damage. The forced swimming test (FST) and sucrose preference test (SPT) were applied for measuring depression-like behavior. The locomotor activity test (LAT) was performed to examine mTBI-J treatment effects on motor function. After the behavioral experiments, the dorsal hippocampus (dHip) and ventral hippocampus (vHip) were dissected out for western blotting to examine the expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB). Finally, a TrkB agonist 7,8-DHF was injected intraperitoneally to evaluate its therapeutic effect on the mTBI-J induced behavioral abnormalities at the early adult age. Results showed that a mild brain edema occurred, but no significant neural damage was found in the mTBI-J treated animals. In addition, a significant increase of depression-like behaviors was observed in the mTBI-J treated animals; the FST revealed an increase in immobility, and a decrease in sucrose consumption was found in the mTBI-J treated animals. There were no differences observed in the total distance traveled of the LAT and the fall latency of the rotarod test. The hippocampal BDNF expression, but not the TrkB, were significantly reduced in mTBI-J, and the mTBI-J treatment-induced depression-like behavior was lessened after four weeks of 7,8-DHF administration. Collectively, these results indicate that even a mild juvenile TBI treatment that did not produce motor deficits or significant histological damage could have a long-term adverse effect that could be sustained to adulthood, which raises the depression-like behavior in the adult age. In addition, chronic administration of 7,8-DHF lessens the mTBI-J treatment-induced depression-like behaviors in adult rats. We suggest the potential usage of 7,8-DHF as a therapeutic agent for preventing the long-term adverse effect of mTBI-J.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age

Yang

Hung

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Formulating new generalizations, we saw that they are easily integrated into the existing system of knowledge and complement the ideas of nervism developed over the past 250 years [ 155 ]. This allowed us to reach the theory of a typical pathological process , which has been actively developed in recent decades [ 106 ]. It turned out that the concepts of nitric oxide and superoxide anion radical cycles [ 95 – 106 ], the principles of cyclicity and the holographic principle [ 101 – 103 , 105 ], which we have been working on over the past few decades, complement the theory of a typical pathological process well [ 106 , 156 – 161 ].…”

Section: Perspectivesmentioning

confidence: 99%

Tissue-Engineered Constructions in Biophysics, Neurology and Other Fields and Branches of Medicine

2022

Self Cite

View full text Add to dashboard Cite

This paper describes the gangliopexy method, a method for creating a new center of local neurohumoral regulation, based on the formation of new connections discovered between the nervous system and the vascular system. The prospects for the development of this method are studied. At the same time, novel concepts about the cycles of nitric oxide and the superoxide anion radical are introduced. A possible role of these cycles is examined in the protection of cells and the body as a whole against oxidative and nitrosative stress, which develops when (in 5–30% of cases) destructive changes in the displaced ganglion lead to vascular complications and an increased risk of mortality. Mechanisms that can protect nerve cells, prevent the development of destructive changes in these cells and reduce the risk of mortality are also investigated.

show abstract

“…During this free radical resonance, increased concentrations of • NO and interact with each other at very high rates and end in the formation of highly toxic and highly reactive compounds, • NO 2 , • OH radicals, and peroxynitrites, which again turn into • NO, • NO 2 and • OH radicals, thereby closing the pathogenetic cycle [98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116]. These are reactions that are capable of free radical chain processes that destroy almost all components of cells and subcellular structures.…”

Section: Problems and Prospectsmentioning

confidence: 99%

“…In formulating new generalizations, we have seen that they are easily integrated into the existing knowledge system [100,117,[120][121][122][123]137]. This allowed us to reach the theory of a typical pathological process [99], which has been actively developed in recent decades [138][139][140][141][142][143]. It turned out that the concepts of cycles • NO and [92,100,116,117,122,130,144,145], the principles of cyclicity and the holographic principle [121,137] complement well the theory of a typical pathological process [99,[137][138][139][140][141][142][143].…”

Section: Problems and Prospectsmentioning

confidence: 99%

“…This allowed us to reach the theory of a typical pathological process [99], which has been actively developed in recent decades [138][139][140][141][142][143]. It turned out that the concepts of cycles • NO and [92,100,116,117,122,130,144,145], the principles of cyclicity and the holographic principle [121,137] complement well the theory of a typical pathological process [99,[137][138][139][140][141][142][143]. We consider the following conclusions to be the most significant generalizations: (1) pathology begins with a violation of normal regulatory cycles that maintain basic biochemical and physiological parameters within normal limits; (2) cycles of nitric oxide and superoxide anion radical with heme-containing proteins and antioxidant protection systems do not allow direct interaction of • NO and • O 2 and the formation of nitrogen dioxide ( • NO 2 ) and • OH radicals capable of destroying almost all components of cells and subcellular structures; (3) violation of the above cycles of • NO and • O 2 lead to a transition from the norm to the development of various pathological processes.…”

Section: Problems and Prospectsmentioning

confidence: 99%

See 1 more Smart Citation

Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

Реутов

Sorokina

2022

BIOPHYSICS

Self Cite

View full text Add to dashboard Cite

The brain and gastrointestinal tract are the most important organs responsible for detecting, transmitting, integrating, and responding to signals coming from the internal and external environment. A bidirectional system of neurohumoral communication (the "intestine-brain" axis) combines the activity of the intestine and brain (or brain and intestine) of a person. It affects human development and behavior. This paper analyzes the literature data on the existence of a relationship between the central and enteral nervous systems. Based on data on the number of neurons in the enteral nervous system (approximately 250 million nerve cells), the concept of a "second brain" in the intestine has been proposed in foreign literature, which, by its influence on the brain, can have a more powerful influence than the spinal cord (approximately 10 million neurons) with its autonomic nervous system. However, it turned out that Russian scientists, academicians of the Academy of Sciences of the Soviet Union I.P. Pavlov, K.M. Bykov, and A.M. Ugolev, analyzed cortical-visceral relationships in the 20th century and wrote about the existence of a connection between the central and enteral nervous systems. One of the urgent problems of modern physiology, pathophysiology, biophysics, biochemistry, and medicine is to clarify the causal relationship between the central and enteral nervous systems, as well as between neurological, mental, and gastrointestinal diseases in order to combine the efforts of specialists of various medical and biological profiles to solve urgent medical problems.

show abstract

A Model of Glutamate Neurotoxicity and Mechanisms of the Development of the Typical Pathological Process

Cited by 16 publications

References 82 publications

Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age

Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age

Tissue-Engineered Constructions in Biophysics, Neurology and Other Fields and Branches of Medicine

Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

Contact Info

Product

Resources

About