A Model of Intracranial Pulsations

Egnor, Michael; Rosiello, Arthur; Zheng, Lili

doi:10.1159/000050440

Cited by 73 publications

(62 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Egnor and associates reported simulation of the rebound sign by an electrical circuit model, in which the cyst was represented with a capacitor to predict the flow within the arachnoid cyst. 32 In our case, the arachnoid cyst was noncommunicating, and the rebound sign was not observed. Plausible explanations for the lack of a rebound sign include the size and location of the arachnoid cyst, the elastic reactance of the cyst wall, and the volume or '"thickness" of the brain tissue surrounding the cyst.…”

Section: Discussionmentioning

confidence: 43%

“…5,6,16,32 Moreover, in the normal intracranial environment, synchronization among arterial, CSF, and venous velocity waveforms has been demonstrated by evaluation of the velocities of these components at the axial slice of the cervical region. [13][14][15]17 However, the Windkessel effect should prevent transmission of arterial pulse waveforms to CSF through the capillaries 32 because the compliance of the arterial wall will change pulsatile arterial flow to stationary flow. Therefore, the to-and-fro motion of the CSF within a cardiac cycle can be primarily attributed to the propagation of pressure from the cerebral arteries rather than the capillaries.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Visualization of Pulsatile CSF Motion Around Membrane-like Structures with both 4D Velocity Mapping and Time-SLIP Technique

et al. 2015

View full text Add to dashboard Cite

Purpose: We compared the depiction of pulsatile CSF motion obtained by 4-dimensional phase-contrast velocity mapping (4D-VM) with that by time-spatial labeling inversion pulse (time-SLIP) technique in the presence of membrane structures.Materials and Methods: We compared the 2 techniques using a flow phantom comprising tubes with and without a thin rubber membrane and applied the techniques to 6 healthy volunteers and 2 patients to analyze CSF dynamics surrounding thin membrane structures, such as the Liliequist membrane (LM), or the wall of an arachnoid cyst.Results: Phantom images exhibited propagation of the flow and pressure gradient beyond the membrane in the tube. In contrast, fluid labeled by the time-SLIP technique showed little displacement from the blockage of spin travelling by the membrane. A similar phenomenon was observed around the LM in healthy volunteers and the arachnoid cyst wall in a patient.Conclusion: Four-dimensional phase-contrast velocity mapping permitted visualization of the propagation of CSF pulsation through the intracranial membranous structures. This suggests that 4D-VM and the time-SLIP technique provide different information on flow and that both techniques are useful for classifying the pathophysiological status of CSF and elucidating the propagation pathway of CSF pulsation in the cranium.

show abstract

Section: Discussionmentioning

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Visualization of Pulsatile CSF Motion Around Membrane-like Structures with both 4D Velocity Mapping and Time-SLIP Technique

et al. 2015

View full text Add to dashboard Cite

show abstract

“…These findings suggest MS patients experience changes in the cerebral hydraulic regulatory mechanism, which normally maintains Monro-Kellie homeostasis (26). This mechanism utilizes the CSF to dampen the arterial pulse, ensuring the smooth flow of blood through the cerebral capillary bed (27).…”

Section: Discussionmentioning

confidence: 99%

Cine cerebrospinal fluid imaging in multiple sclerosis

Magnano

Schirda

Weinstock‐Guttman

et al. 2012

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius in multiple sclerosis (MS) patients and healthy controls (HC) using cine phase contrast imaging. Materials and Methods:In all, 67 MS patients (48 relapsing-remitting [RR] and 19 secondary-progressive [SP]), nine patients with clinically isolated syndrome (CIS), and 35 age-and sex-matched HC were examined. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and magnetic resonance imaging (MRI) disease outcomes.Results: Significantly decreased CSF net flow was detected in MS patients compared to HC (À3.7 vs. À7.1 mL/beat, P ¼ 0.005). There was a trend for increased net positive flow between SP, RR, and CIS patients. Altered CSF flow and velocity measures were associated with more severe T1 and T2 lesion volumes, lateral and fourth ventricular volumes, and third ventricular width in MS and CIS patients (P < 0.01 for all). In CIS patients, conversion to clinically definite MS in the following year was related to decreased CSF net flow (P ¼ 0.007). There was a trend between increased annual relapse rate and altered CSF flow/velocity measures in RRMS patients (P < 0.05).Conclusion: CSF flow dynamics are altered in MS patients. More severe clinical and MRI outcomes in RRMS and CIS patients relate to altered CSF flow and velocity measures.

show abstract

“…One hypothesis put forward by Bering [5] and further developed by Egnor et al [6,7] is the hyperdynamic choroid plexus pulsation theory, which suggests that ventricle dilatation is a result of a sequence of hyperdynamic pulsation of choroid plexus: obstruction of the subarachnoid space leads to decrease in artery pulsation, while choroidal artery pulsation is increased and hyperdynamic, which eventually increases the intraventricular pressure to result in ventricle dilatation. However, it 0306-9877/$ -see front matter Ó 2008 Elsevier Ltd. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%