For an open channel with cascade pumping stations, the water level immediately upstream of the pumping station should be kept constant to ensure pumping stability and lining safety. In this study, a simple method was proposed to determine the control time of the pumping station to ensure a stable water level immediately upstream of the pumping station using reverse analysis. The variable discharge process and fixed water level were taken as the upstream and downstream boundaries of the one-dimensional open channel hydrodynamic model, and the discharge process of the pumping station was obtained under ideal conditions. The control time was determined by the equivalent water volume change considering the step change of the discharge of the pumping station. A case study was performed using the Jiaodong water diversion project from Songzhuang sluice to Huibu pumping station (G1–P1), and the effects of the initial discharge, variable discharge, and downstream water level on the control time were investigated. The results show that (1) the larger the initial discharge, the shorter the control time; (2) increasing the upstream discharge reduced the control time, while decreasing the upstream discharge increased the control time; (3) the control time decreased with the increase of the water depth immediately upstream of the pumping station.