A Model to Predict the Severity of Acute Pancreatitis Based on Serum Level of Amylase and Body Mass Index

Kumaravel, Arthi; Stevens, Tyler; Papachristou, Georgios I.; Muddana, Venkata; Bhatt, Amit; Lee, Peter Junwoo; Holmes, Jordan; López, Rocío; Whitcomb, David C.; Parsi, Mansour A.

doi:10.1016/j.cgh.2015.03.018

Cited by 21 publications

(14 citation statements)

References 31 publications

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“…BUN > 25 mg/dL was also associated with a higher mortality risk in acute pancreatitis compared to patients with BUN ≤ 25 mg/dL (OR: 5.06; 95% CI: 1.37–18.67; P = 0.015), which is consistent with a previous report [5]. Additionally, contrary to the report by Kumaravel et al [54], our study showed that BMI was not associated with organ failure and mortality in acute pancreatitis. These differences may be due to the variations among studies regarding the proportion of different etiology and number of obese patients, as evidenced by the fact that only a small proportion of patients with alcohol etiology and obesity were enrolled in our study (Table 1).…”

Section: Discussionsupporting

confidence: 89%

Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis

Hong

Lin

Zippi

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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Background and Aims To investigate the association between serum albumin levels within 24 hrs of patient admission and the development of persistent organ failure in acute pancreatitis. Methods A total of 700 patients with acute pancreatitis were enrolled. Multivariate logistic regression and subgroup analysis determined whether decreased albumin was independently associated with persistent organ failure and mortality. The diagnostic performance of serum albumin was evaluated by the area under Receiver Operating Characteristic (ROC) curves. Results As levels of serum albumin decrease, the risk of persistent organ failure significantly increases (Ptrend < 0.001). The incidence of organ failure was 3.5%, 10.6%, and 41.6% in patients with normal albumin and mild and severe hypoalbuminaemia, respectively. Decreased albumin levels were also proportionally associated with prolonged hospital stay (Ptrend < 0.001) and the risk of death (Ptrend < 0.001). Multivariate analysis suggested that biliary etiology, chronic concomitant diseases, hematocrit, blood urea nitrogen, and the serum albumin level were independently associated with persistent organ failure. Blood urea nitrogen and the serum albumin level were also independently associated with mortality. The area under ROC curves of albumin for predicting organ failure and mortality were 0.78 and 0.87, respectively. Conclusion A low serum albumin is independently associated with an increased risk of developing of persistent organ failure and death in acute pancreatitis. It may also be useful for the prediction of the severity of acute pancreatitis.

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Section: Discussionsupporting

confidence: 89%

Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis

Hong

Lin

Zippi

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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“…Moreover, cytokines have been identified to serve as the mediators of local and systemic manifestations of pancreatitis, and proinflammatory cytokines such as TNF-a, IL-6, IL-1b, and IL-8 have been reported to be able to aggravate pancreatitis [29,30]. In addition, the serum levels of amylase serve as a common indicator for predicting the course of AP [31]. Although the role of B3GALT5-AS1 in AP has not been deciphered so far, the results of the present study indicate that B3GALT5-AS1 might be having a protective role in AP.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The pivotal role and mechanism of long non-coding RNA B3GALT5-AS1 in the diagnosis of acute pancreatitis

Wang

Zhao

Wang

2019

Artificial Cells, Nanomedicine, and Biotechnology

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The present study planned to dig the potential impacts of long non-coding RNA B3GALT5-AS1 in acute pancreatitis (AP). A total of 66 patients who were diagnosed with AP using ultrasonic imaging were enrolled in the study. Expression levels of B3GALT5-AS1 in the serum of AP patients were determined. Afterwards, rat pancreatic AR42J acinar cells were disposed with caerulein to produce AP-like injury. The role and molecular mechanisms of B3GALT5-AS1 in AP were explored through in vitro cell experiments. The levels of lncRNA B3GALT5-AS1 were observed to be lessened in patients with AP relative to healthy controls. In addition, caerulein was observed to induce injuries in the AR42J cells (depressed cell viability, enhanced cell apoptosis, cytokines production, and levels of amylase). Overexpression of B3GALT5-AS1 alleviated the caerulein-produced injury in the AR42J cells. Moreover, it was determined that miR-203 showed a downside expression by B3GALT5-AS1 regulation, and the overexpression of B3GALT5-AS1 retrained caerulein-produced injury through the suppression of miR-203. In addition, it was observed that miR-203 lessened the level of nuclear factor interleukin-3 (NFIL3) and that NFIL3 was targeted by miR-203. Lastly, the impacts of B3GALT5-AS1 on caerulein-induced cell injury were manifested through the NF-jB signalling pathway. The data from the present study revealed that in patients with AP, B3GALT5-AS1 is expressed in reduced amounts. Overexpression of B3GALT5-AS1 may alleviate caerulein-induced cell injury in AR42J cells through the regulation of miR-203/NFIL3 axis and by inhibiting the activation of the NF-jB signals ARTICLE HISTORY

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“…The clinical usefulness of this nomogram was evaluated by decision curve analysis [18,19]. Area under the ROC curves (AUC) was also used to evaluate the discriminative capacity of the nomogram [20]. Risk score at 0.2-0.4 were considered as low risk, 0.4-0.7 as medium risk and 0.7-0.9 as high risk.…”

Section: Discussionmentioning

confidence: 99%

A Nomogram for Individual Prediction of Poor Prognosis After Radical Surgery in Patients with Primary Pancreatic Duct Adenocarcinoma

et al. 2020

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Background: Pancreatic cancer is a highly malignant tumor characterized by poor prognosis. TNM stage cannot always provide accurate prediction of prognosis, which is vital for individualized treatment. Therefore, a novel way to identify patients with poor prognosis after radical surgery is urgently needed. Material/Methods: The nomogram was established based on a discovery cohort that included 554 patients with PDAC who had received radical surgery from 2012 to 2016. The clinicopathological data were collected. Poor prognosis was evaluated using 25 features, in which appropriate features for a prediction model were identified. A prediction model incorporating the selected features was established. The discriminative capacity was assessed by C-index, calibration by calibration plot, and clinical usefulness by decision curve. The bootstrapping approach was used to perform internal validation. Results: Characteristics included in the nomogram were coronary artery disease and stroke history, elevated CA125, AJCC stage >II, R0 resection, operating time >6 h, poor differentiation, nerve invasion, length of stay >30 days, and postoperative complications. A C-index of 0.713 indicated good discrimination of the prediction model, and the calibration curve showed acceptable calibration. Survival analysis showed that this model had better discriminative capacity than the AJCC staging system and could distinguish relatively good prognosis from poor prognosis in patients at stage II (especially IIa) and IV. Conclusions: Our study presents a valid and practical model to predict prognosis of pancreatic cancer patients, which contributes to individualized therapy by assisting surgeons to predict poor prognosis in patients who received radical surgery.

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A Model to Predict the Severity of Acute Pancreatitis Based on Serum Level of Amylase and Body Mass Index

Cited by 21 publications

References 31 publications

Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis

Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis

RETRACTED ARTICLE: The pivotal role and mechanism of long non-coding RNA B3GALT5-AS1 in the diagnosis of acute pancreatitis

A Nomogram for Individual Prediction of Poor Prognosis After Radical Surgery in Patients with Primary Pancreatic Duct Adenocarcinoma

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