A Modeling Study on Inspired CO2 Rebreathing Device for Sleep Apnea Treatment by Means of CFD Analysis and Experiment

Sleep apnea: a review of diagnostic sensors, algorithms, and therapies

“…Exploratory data analysis of data in different transform domains may be useful and important to the development of new methods. Domain expertise and computational methods may be applied to produce novel features and phenotypes that have an interpretable physiological basis, and may be investigated and validated to improve the understanding of the biological basis for sleep apnea (Fernandez et al 2017).…”

“…It has been shown that the apnoea-hypopnoea index (AHI) can be decreased by the addition of as little as 400-600 ml of dead space (Khayat et al 2003, 2013. Though there are possible adverse effects to the cardiovascular system (Khayat et al 2003, Shokoueinejad et al 2017, CO 2 rebreathing has been shown to be highly effective in preventing central apnea and instabilities in sleep caused by hypoxic exposure and CHF, and over many months in CPAP-treated OSA patients with 'residual' central apnea, i.e. socalled 'complex' sleep apnea (Gilmartin et al 2005, Thomas 2005).…”