A Modular Heat-Shrink-Packaged Check Valve With High Pressure Shutoff

Lo, Ronalee; Meng, Ellis

doi:10.1109/jmems.2011.2163301

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…The four-part MEMS check valve (Lo and Meng 2011) consisted of a valve seat, pressure limiter, and spacer plate made of SU-8 2100 (MicroChem, Newton, MA), and an s-shaped arm valve plate made from MDX-4-4210 (10:1 base-to-curing agent ratio, Dow Corning, Midland, MI). The components were aligned and held in a custom fixture and covered with 1.3:1 shrink ratio fluorinated ethylene propylene (FEP) heat-shrink tubing (22G, Zeus Industrial Products Inc., Orangeburg, SC).…”

Section: Methodsmentioning

confidence: 99%

“…Flow rate was measured in a calibrated micropipet (Accu-Fill 90, Becton, Dickinson and Company, NJ) attached to the valve outlet. The valve was kept dry prior to the first application of pressurized water, but was submerged in water before the second run to prevent stiction, which was observed previously and described in (Lo and Meng 2011). …”

Section: Methodsmentioning

confidence: 99%

“…7) was then cured at 80 °C for approximately 45 minutes. A 30-gauge non-coring needle was used to fill the reservoir with deionized water for testing as previously demonstrated (Lo et al 2009). …”

Section: Methodsmentioning

confidence: 99%

“…The integrated check valve described in (Lo et al 2009) had a relatively high cracking pressure (~10 kPa or 76 mmHg) and was integrated into a rectangular cannula, which is difficult to secure and seal with sutures. Here we chose to use an in-line check valve with high pressure shutoff as previously described (Lo and Meng 2009; Lo and Meng 2011). The valve was designed to open at low forward pressures during drug delivery, but to be closed under back pressure and at excessive forward pressures greater than a preset threshold to prevent accidental dosing under pump malfunction or other unexpected conditions.…”

Section: Designmentioning

confidence: 99%

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An implantable MEMS micropump system for drug delivery in small animals

Gensler

Sheybani

et al. 2012

Biomed Microdevices

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139

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We present the first implantable drug delivery system for controlled dosing, timing, and location in small animals. Current implantable drug delivery devices do not provide control over these factors or are not feasible for implantation in research animals as small as mice. Our system utilizes an integrated electrolysis micropump, is refillable, has an inert drug reservoir for broad drug compatibility, and is capable of adjustment to the delivery regimen while implanted. Electrochemical impedance spectroscopy (EIS) was used for characterization of electrodes on glass substrate and a flexible Parylene substrate. Benchtop testing of the electrolysis actuator resulted in flow rates from 1 to 34 μL/min on glass substrate and up to 6.8 μL/min on Parylene substrate. The fully integrated system generated a flow rate of 4.72 ± 0.35 μL/min under applied constant current of 1.0 mA while maintaining a power consumption of only ~3 mW. Finally, we demonstrated in vivo application of the system for anti-cancer drug delivery in mice.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Designmentioning

confidence: 99%

See 2 more Smart Citations

An implantable MEMS micropump system for drug delivery in small animals

Gensler

Sheybani

et al. 2012

Biomed Microdevices

Self Cite

139

View full text Add to dashboard Cite

show abstract

“…Drug delivery was controlled either by manually applied pressure [94-96] or driven by electrolysis-actuated pumping [67, 68, 97-99]. The pressure-responsive one-way valve opened only under dosing conditions (elevated reservoir pressure) and prevented back flow of fluids into the device [94-96, 100, 101]. Low power operation allows wireless activation of drug delivery (shown in vitro) [23].…”

Section: Electrolysis-based Drug Delivery Micropumpsmentioning

confidence: 99%

MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications

Meng

Hoang

2012

Advanced Drug Delivery Reviews

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Innovation in implantable drug delivery devices is needed for novel pharmaceutical compounds such as certain biologics, gene therapy, and other small molecules that are not suitable for administration by oral, topical, or intravenous routes. This invasive dosing scheme seeks to directly bypass physiological barriers presented by the human body, release the appropriate drug amount at the site of treatment, and maintain the drug bioavailability for the required duration of administration to achieve drug efficacy. Advances in microtechnologies have led to novel MEMS-enabled implantable drug infusion pumps with unique performance and feature sets. In vivo demonstration of micropumps for laboratory animal research and preclinical studies include acute rapid radiolabeling, short-term delivery of nanomedicine for cancer treatment, and chronic ocular drug dosing. Investigation of MEMS actuators, valves, and other microstructures for on-demand dosing control may enable next generation implantable pumps with high performance within a miniaturized form factor for clinical applications.

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BioMEMS in drug delivery

Nuxoll

2013

Advanced Drug Delivery Reviews

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A Modular Heat-Shrink-Packaged Check Valve With High Pressure Shutoff

Cited by 5 publications

References 19 publications

An implantable MEMS micropump system for drug delivery in small animals

An implantable MEMS micropump system for drug delivery in small animals

MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications

BioMEMS in drug delivery

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