The 23rd International Electronic Conference on Synthetic Organic Chemistry 2019
DOI: 10.3390/ecsoc-23-06504
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A Molecular Docking of New 9β-Halogenated Prostaglandin Analogues

Abstract: Prostaglandins (PGs) with cytoprotective activity were studied for a long time, and a few PGE1 and PGE2 stable analogues were promoted as drugs: arbaprostil, enprostil, misoprostol, and rioptostol. Similarly, nocloprost, a 9β-chlorine prostaglandin analogue, and many 9β- and 11β-substituted prostaglandins were synthesized and studied for their biological activity. We previously synthesized new 9β-halogenated prostaglandins with an ester group at the carbon atom 6 (PGs numbering) by the reaction of a δ-lactone … Show more

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