A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures

Kizer, Megan E.; Linhardt, Robert J.; Chandrasekaran, Arun Richard; Wang, Xing

doi:10.1002/smll.201805386

Cited by 21 publications

(18 citation statements)

References 154 publications

(192 reference statements)

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“…Since they are formed by base pairing of DNA, thermal stability and susceptibility to nucleases can both pose problems for certain applications. These challenges are solvable, and many of these aspects are currently being addressed by this relatively new field (150–152).…”

Section: Critical Analysis and Discussionmentioning

confidence: 99%

DNA nanotechnology approaches for microRNA detection and diagnosis

Chandrasekaran

Punnoose

Zhou

et al. 2019

Nucleic Acids Research

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112

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MicroRNAs are involved in the crucial processes of development and diseases and have emerged as a new class of biomarkers. The field of DNA nanotechnology has shown great promise in the creation of novel microRNA biosensors that have utility in lab-based biosensing and potential for disease diagnostics. In this Survey and Summary, we explore and review DNA nanotechnology approaches for microRNA detection, surveying the literature for microRNA detection in three main areas of DNA nanostructures: DNA tetrahedra, DNA origami, and DNA devices and motifs. We take a critical look at the reviewed approaches, advantages and disadvantages of these methods in general, and a critical comparison of specific approaches. We conclude with a brief outlook on the future of DNA nanotechnology in biosensing for microRNA and beyond.

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Section: Critical Analysis and Discussionmentioning

confidence: 99%

DNA nanotechnology approaches for microRNA detection and diagnosis

Chandrasekaran

Punnoose

Zhou

et al. 2019

Nucleic Acids Research

Self Cite

112

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“…Later, DNA origami-based nanostructure gradually turned to application fields. In addition, there are some excellent reviews that summarize the advancement of DNA origami in application, such as in precise manipulation of chemical and enzymatic reactions, assembly of plasmonic antennas, drug delivery, biocomputing, three-dimensional lattice engineering of nanoparticles (NPs), nanofabrication in surface engineering [22][23][24][25][26][27] and so on. This review covers several signal readout strategies that are widely used in DNA origami-enabled biosensors and presents the sensing mechanism, potential, and challenge in practical application.…”

Section: Dna Origamimentioning

confidence: 99%

DNA Origami-Enabled Biosensors

Wang

Zhou

et al. 2020

Sensors

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Biosensors are small but smart devices responding to the external stimulus, widely used in many fields including clinical diagnosis, healthcare and environment monitoring, etc. Moreover, there is still a pressing need to fabricate sensitive, stable, reliable sensors at present. DNA origami technology is able to not only construct arbitrary shapes in two/three dimension but also control the arrangement of molecules with different functionalities precisely. The functionalization of DNA origami nanostructure endows the sensing system potential of filling in weak spots in traditional DNA-based biosensor. Herein, we mainly review the construction and sensing mechanisms of sensing platforms based on DNA origami nanostructure according to different signal output strategies. It will offer guidance for the application of DNA origami structures functionalized by other materials. We also point out some promising directions for improving performance of biosensors.

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“…Based on the base-pairing principle, a variety of nucleic acid nanostructure constructing methods have already been reported, for example, tilebased assembly [13][14][15] and DNA origami. [16][17][18] Due to the excellent structural programmability and addressability, nucleic acid nanoarchitectures have shown great application potential in the fields of nanophotonics, 19,20 nanoelectronics, 21,22 and biomedicine, [23][24][25][26][27] as well as logic computing and information process.…”

Section: Introductionmentioning

confidence: 99%

Logic devices based on nucleic acid self‐assembly

Shang

Liu

et al. 2021

InfoMat

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Nucleic acids are natural macromolecules with the ability to store and transmit information based on the strict base-pairing principle. Beyond the natural nucleic acid double helixes, various DNA/RNA nanostructures with customized geometries and functionalities have been fabricated. Featured with programmability and sequence-dependent responsiveness, DNA/RNA nanostructures have been employed for the rational design and construction of logic devices. When stimulated by internal molecular triggers and/or external stimuli, these logic gate devices can operate at nanoscale level in complex biological environments, performing logic operations and producing corresponding outputs. In this minireview, we summarize the recent advances of nucleic acid logic devices, which are responsive to various stimuli, including DNA/RNA strands, metal ions, small molecules, peptides, proteins, photo-irradiation, pH changes, and so forth. The applications of these devices in biosensing and biofunction regulation are also included. In the last part of the present study, we discuss the remaining challenges and perspectives of nucleic acid logic devices.

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A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures

Cited by 21 publications

References 154 publications

DNA nanotechnology approaches for microRNA detection and diagnosis

DNA nanotechnology approaches for microRNA detection and diagnosis

DNA Origami-Enabled Biosensors

Logic devices based on nucleic acid self‐assembly

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