A molecularly imprinted electrochemical sensor based on highly selective and an ultra-trace assay of anti-cancer drug axitinib in its dosage form and biological samples

Çetinkaya, Ahmet; Kaya, Sezai; Özçelikay, Göksu; Atici, Esen Bellur; Ozkan, Sibel A.

doi:10.1016/j.talanta.2021.122569

Cited by 29 publications

(10 citation statements)

References 22 publications

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“…The other study is based on a molecularly imprinted polymer (MIP) sensor. 35 The MWCNTs/Fe 2 O 3 @chitosan NC/GCE sensor is more sensitive and has lower LOD values compared to the bare electrodes. Even though the MIP-based sensor has lower LOD values and good selectivity, this present work offers better stability and a better understanding of the electron transfer mechanism on the GCE surface with the density functional theory.…”

Section: Resultsmentioning

confidence: 98%

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Detection of Axitinib Using Multiwalled Carbon Nanotube-Fe₂O₃/Chitosan Nanocomposite-Based Electrochemical Sensor and Modeling with Density Functional Theory

et al. 2022

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In this study, axitinib (AXI), a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinase and used as a second-generation targeted drug, was investigated electrochemically under optimized conditions using multiwalled carbon nanotubes/iron(III) oxide nanoparticle–chitosan nanocomposite (MWCNT/Fe 2 O 3 @chitosan NC) modified on the glassy carbon electrode (GCE) surface. Characterization of the modified electrode was performed using scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The adsorptive stripping differential pulse voltammetric (AdSDPV) technique was used for the sensitive, rapid, and precise detection of AXI. The current peak obtained with the MWCNT/Fe 2 O 3 @chitosan NC modified electrode was 23 times higher compared to the bare electrode. The developed modified electrode showed excellent electrocatalytic activity in AXI oxidation. Under optimized conditions, the effect of supporting electrolyte and pH was investigated, and 0.1 M H 2 SO 4 was chosen as the electrolyte with the highest peak current for the target analyte. In the concentration range of MWCNT/Fe 2 O 3 @chitosan NC/GCE, 6 × 10 –9 and 1 × 10 –6 M, the limit of detection (LOD) and limit of quantification (LOQ) values were calculated to be 0.904 and 0.0301 pM, respectively. Tablet and serum samples were used for the applicability of the developed sensor, relative standard deviation (RSD) values for all samples were below 2%, and the recovery results were 99.23 and 101.84%, respectively. The MWCNT/Fe 2 O 3 @chitosan NC/GCE designed to determine AXI demonstrated the applicability, selectivity, precision, and accuracy of the sensor. The mechanism of electron transfer from the modified GCE surface to the analyte solution is studied via modeling the modified GCE surface by the density functional theory (DFT) method at B3LYP/6-311+g(d,p) and M062X/6-31g(d,p) levels. We observed that the iron oxide nanoparticles play an important role in channeling electron flow from the analyte solution to the MWCNT-coated GCE electrode surface. Adsorption of the nanocomposite material onto the GCE surface occurs via strong electrostatic interactions, including ionic and hydrogen bond formations. During the adsorption-controlled oxidation process of the axitinib, the electrons are transferred via the highest occupied molecular orbital (HOMO) localized on the iron oxide moiety to the lowest unoccupied molecular orbital (LUMO) of the MWCNT/GCE surface.

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Section: Resultsmentioning

confidence: 98%

“…Cetinkaya et al evaluated the electrochemical behavior of AXI on GCE and boron-doped diamond electrode (BDDE). The other study is based on a molecularly imprinted polymer (MIP) sensor . The MWCNTs/Fe 2 O 3 @chitosan NC/GCE sensor is more sensitive and has lower LOD values compared to the bare electrodes.…”

Section: Resultsmentioning

confidence: 99%

Detection of Axitinib Using Multiwalled Carbon Nanotube-Fe₂O₃/Chitosan Nanocomposite-Based Electrochemical Sensor and Modeling with Density Functional Theory

et al. 2022

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“…Electrochemical characterization of the PGE/MIP. The CV technique has been widely adopted by many researchers [57][58][59] to investigate several polymerization stages as shown in Fig. 5, using a ferrocyanide/ferricyanide redox probe.…”

Section: Characterization Of the Electropolymerization Processmentioning

confidence: 99%

Electrochemical sensor based on bio-inspired molecularly imprinted polymer for sofosbuvir detection

Soliman,

Mahmoud,

Elzanfaly

et al. 2023

RSC Adv.

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“…16 Molecularly imprinted polymer (MIP) structures are created when a functional monomer surrounds the target molecule via hydrogen bonding. 17 After the target molecule's removal process, specific cavities for the target molecule are formed. 18 When the MIP-based electrochemical sensor is applied to the pharmaceutical dosage forms and/or biological samples, the sensor recognizes the target molecule selectively without interferences due to the artificial receptors created in the polymeric matrix.…”

Section: Introductionmentioning

confidence: 99%

The electrochemical quantitation method for sugammadex via a molecularly imprinted polymer-based sensor

Özçelikay

Çetinkaya

Atici³

et al. 2023

Anal. Methods

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A molecularly imprinted electrochemical sensor based on highly selective and an ultra-trace assay of anti-cancer drug axitinib in its dosage form and biological samples

Cited by 29 publications

References 22 publications

Detection of Axitinib Using Multiwalled Carbon Nanotube-Fe₂O₃/Chitosan Nanocomposite-Based Electrochemical Sensor and Modeling with Density Functional Theory

Detection of Axitinib Using Multiwalled Carbon Nanotube-Fe₂O₃/Chitosan Nanocomposite-Based Electrochemical Sensor and Modeling with Density Functional Theory

Electrochemical sensor based on bio-inspired molecularly imprinted polymer for sofosbuvir detection

The electrochemical quantitation method for sugammadex via a molecularly imprinted polymer-based sensor

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A molecularly imprinted electrochemical sensor based on highly selective and an ultra-trace assay of anti-cancer drug axitinib in its dosage form and biological samples

Cited by 29 publications

References 22 publications

Detection of Axitinib Using Multiwalled Carbon Nanotube-Fe2O3/Chitosan Nanocomposite-Based Electrochemical Sensor and Modeling with Density Functional Theory

Detection of Axitinib Using Multiwalled Carbon Nanotube-Fe2O3/Chitosan Nanocomposite-Based Electrochemical Sensor and Modeling with Density Functional Theory

Electrochemical sensor based on bio-inspired molecularly imprinted polymer for sofosbuvir detection

The electrochemical quantitation method for sugammadex via a molecularly imprinted polymer-based sensor

Contact Info

Product

Resources

About

Detection of Axitinib Using Multiwalled Carbon Nanotube-Fe₂O₃/Chitosan Nanocomposite-Based Electrochemical Sensor and Modeling with Density Functional Theory

Detection of Axitinib Using Multiwalled Carbon Nanotube-Fe₂O₃/Chitosan Nanocomposite-Based Electrochemical Sensor and Modeling with Density Functional Theory