A Mother-Child Combination Analysis for ABO-HP Interaction in a Bengalee Population

Abstract

Blood samples of 811 mother-child pairs from Bengalee Hindu caste groups were utilised to study the interaction between ABO blood groups and haptoglobin systems. There was no significant difference in the haptoglobin distribution between mothers and children. Significantly higher incidences of HP*1 were noted in the offspring born to ABO-incompatible mother-child combinations in comparision to offspring born to ABO-compatible combinations.

Maternal fetal interaction in the ABO system: A comparative analysis of healthy mother and couples with spontaneous abortion in Bengalee population

“…On the other hand, the parents of the newborns and the aborted foeti revealed significant heterogeneity ( P < 0.05) in the distribution of the ABO blood groups (Table 3) due to significantly ( P < 0.05) lower O allele among the parents of the foeti compared with that of the parents of the newborns. Nevertheless, the distribution ABO blood group allele frequencies were found to be in corroboration with previous works on Bengalee population (Bandyopadhyay and Ghoshal Roy,2005; Bandyopadhyay,1994a,b).…”

“…Trend of higher frequency of A allele and lower frequency of O allele among the father compared with the frequencies of those alleles among the mothers seem to be the reason for the aforementioned phenomenon. However, the ABO allele frequencies of the couples were found to be in corroboration with previous studies on Bengalee population (Bandyopadhyay and Ghoshal Roy,2005; Bandyopadhyay,1993,1994a,b). Aborted foeti also revealed higher frequency of A allele and a lower frequency of O allele compared with those of their mother.…”

“…Incidences of couple combinations for ABO blood groups among the parents of the abortus fetus and the parents of the newborns as presented in the Table 4, indicated significantly higher ( P < 0.05) incidences of ABO incompatibility among the aborted couples (48.53%) compared to that of the parents of the newborns (29.84%), which is well within the range of published work on Bengalee population (Banerjee and Das,1986; Bandyopadhyay,1992a,b; Bandyopadhyay,1993). The effect of fetal wastage and the incidences of couple combination for ABO incompatibility were found to be in well agreement with the non‐Indian (Solish,1969; Clegg,1979; Bottini and Santeusanio,1998; Bottini et al,2001), Indian samples (Jindal and Basu,1981; Sharma and Kapoor,2004), and Bengalee population samples (Banerjee and Das,1986; Bandyopadhyay,1992a,b).…”

“…This study also demonstrated significantly higher ( P < 0.05) ABO incompatibility among the couples with spontaneous abortion (SA) compared with that (Table 4) of ABO compatibles. Regarding the ABO incompatibility in parental and fetomaternal combination, Indian scenario revealed comparatively higher incidences than other countries of the world (Levine and Rosenfiled,1961; Bandyopadhyay,1993,1994a,b). However, all the published studies were based on the samples on reproductive performance of the couples.…”