A mucosa-associated lymphoid tissue (MALT) type lymphoma (marginal zone B-cell lymphoma) from the palatine tonsil

Norval, E. J. G.

doi:10.1080/00313029800169276

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…[ 1 – 5 ] Lymphoma of mucosa-associated lymphoid tissue (MALT) arising from the tonsil is a rare phenomenon. [ 3 , 4 , 6 – 8 ] Morphologically, lymphoma cells may be small to medium sized, presenting as small lymphocytes or with a monocytoid appearance. One-third of gastric MALT lymphomas display plasmacytic differentiation which is also frequently seen in cutaneous and thyroid MALT lymphomas, but very rare in tonsil MALT lymphomas.…”

Section: Introductionmentioning

confidence: 99%

Marginal zone lymphoma of palatine tonsil with prominent plasmacytic differentiation

Jug

Shen

et al. 2018

Medicine

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Rationale:The palatine tonsil is an important component of Waldeyer's ring and a site commonly involved by lymphoma. Interestingly, although it is a site of mucosa-associated lymphoid tissue (MALT), primary MALT lymphoma of the palatine tonsil is rare, especially with prominent plasmacytic differentiation.Patient concerns:A 59-year-old woman presented to the hospital with a 1-month history of odynophagia. The patient had no fever or pruritus during this period and she declared no family history of hematolymphoid malignancy.Diagnosis:Histopathological examination demonstrated effacement of tonsil architecture; normal follicles were replaced by plasmacytoid tumor cells and small lymphocytes. The tumor cells expanded the marginal zone and infiltrated interfollicular regions, as well as scattered residual follicles. Immunostaining showed tumor cells positive for cluster of differentiation (CD)20, CD79a, paired box-5, Mum 1, and B cell lymphoma (Bcl)-2, and negative for CD5, CD 23, cyclin D1, Bcl-6, and CD10. Staining for κ and λ showed prominent light chain restriction. The tumor was classified as tonsil MALT lymphoma with prominent plasmacytic differentiation.Interventions:After the patient was diagnosed with MALT lymphoma with prominent plasmacytic differentiation, she underwent complete surgical resection and radiotherapy.Outcomes:There was no recurrence evident at 6-months follow-up.Lessons:Primary tonsil MALT lymphoma with prominent plasmacytic differentiation is very rare and difficult to distinguish from other B-cell lymphomas with plasmacytoid morphology, such as follicular lymphoma, lymphoplasmacytic lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma. Accurate diagnosis of this entity is important in guiding therapy so as to avoid overtreatment.

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Section: Introductionmentioning

confidence: 99%

Marginal zone lymphoma of palatine tonsil with prominent plasmacytic differentiation

Jug

Shen

et al. 2018

Medicine

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“…MALT lymphoma is clinically characterized by non‐aggressive lymphoma usually occurring in association with autoimmune diseases and chronic inflammation, and pathologically by an extranodal lymphoma consisting of proliferation of centrocyte‐like cells and plasmacytoid cells with lymph follicle formation resembling chronic inflammation. Initially, MALT lymphoma was thought to arise from mucosal lymphoid cells in the gastrointestinal tract, 11,12 but it is actually developed from a variety of extranodal tissues including thyroid, 13 salivary gland, 14 lung, 15 ocular adnexa, 16 thymus, 17 skin, 18 breast, 19 tonsil, 20 gallbladder, 21 liver, 22 and urogenital tract 23 …”

Section: Introductionmentioning

confidence: 99%

Primary extranodal marginal zone B‐cell lymphoma of the mucosa‐associated lymphoid tissue type in the CNS

et al. 2001

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Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type has been reported in various internal organs. Here a case is reported of MALT lymphoma developing in the cerebellopontine (CP) angle in a patient with Sjogren syndrome, and the concept of MALT lymphoma of the CNS is introduced. Pathologically, the tumor showed inflammatory features of reactive lymphocytic infiltration with follicle formation, but there were slightly atypical lymphocytes and plasmacytes with B-cell markers. These cells invaded reactive follicles, showing follicular colonization, and showed aberrant expression indicating their neoplastic nature. A review of the literature revealed eight cases of MALT lymphoma originating from the dura mater and one from the CP angle. The average age of patients was 50 years (range 28-66 years), and all patients were female. The tumors were slow to develop and the patients were cured after surgical removal and/or additional therapies. It is proposed that MALT lymphoma should be considered as a differential diagnosis of inflammatory pseudotumor of the CNS.

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Nasopharynx and Waldeyer’s Ring

Regauer

Pathology of the Head and Neck

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A mucosa-associated lymphoid tissue (MALT) type lymphoma (marginal zone B-cell lymphoma) from the palatine tonsil

Cited by 6 publications

References 19 publications

Marginal zone lymphoma of palatine tonsil with prominent plasmacytic differentiation

Marginal zone lymphoma of palatine tonsil with prominent plasmacytic differentiation

Primary extranodal marginal zone B‐cell lymphoma of the mucosa‐associated lymphoid tissue type in the CNS

Nasopharynx and Waldeyer’s Ring

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