A multi-centre international study of salivary hormone oestradiol and progesterone measurements in ART monitoring

Sakkas, Denny; Howles, Colin M.; Atkinson, Leslie; Borini, Andrea; Bosch, Ernesto; Bryce, Crystal I.; Cattoli, Monica; Copperman, A.B.; Bantel, A Finet de; French, Brian F.; Gerris, Jan; Granger, Steve W.; Grzegorczyk-Martin, Veronika; Lee, Joseph A.; Levy, Michael J.; Matin, Marla J.; Somers, Sara; Widra, E.A.; Alper, Michael M.

doi:10.1016/j.rbmo.2020.10.012

Cited by 17 publications

(12 citation statements)

References 30 publications

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“…Salimetrics (2020Salimetrics ( , 2019 additionally reported time series for one woman with daily progesterone and estradiol assays in serum and saliva for one cycle, which visually show some parallelism. Compared to Salimetrics' (2020Salimetrics' ( , 2019 numbers, independent validations often show smaller saliva-serum correlations; estimates vary widely, and are poorer at lower concentrations (Tivis et al 2005;Shirtcliff et al 2000;Dielen et al 2017;Sun et al 2019;Lu et al 1999;Sakkas et al 2021). The assay manufacturers IBL and Salimetrics do not report raw data of validation studies and only minimal information on the sample of women and their cycles and only rarely show scatter plots which would allow the assessment of heteroskedasticity and influential outliers.…”

Section: Introductionmentioning

confidence: 99%

Not within spitting distance: Salivary immunoassays of estradiol have subpar validity for predicting cycle phase

Arslan

Botzet

Bürkner

et al. 2023

Psychoneuroendocrinology

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Section: Introductionmentioning

confidence: 99%

Not within spitting distance: Salivary immunoassays of estradiol have subpar validity for predicting cycle phase

Arslan

Botzet

Bürkner

et al. 2023

Psychoneuroendocrinology

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“…Various strategies intent on reducing the number of injections by utilizing long-acting gonadotropins or oral medications are already available and are gaining increased acceptance in the field for the treatment of select patient populations [ 10 , 11 ]. Similarly, an emerging strategy to measure salivary estradiol levels may help decrease the need for blood draws during COH [ 12 ]. Recent advancements in portable lower cost ultrasound devices may further simplify follicular and endometrial monitoring by way of convenient mobile facilities and potentially even self-operated endovaginal telemonitoring [ 13 ].…”

Section: Medical Advancementsmentioning

confidence: 99%

The Future of IVF: The New Normal in Human Reproduction

2022

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Increased demand for in vitro fertilization (IVF) due to socio-demographic trends, and supply facilitated by new technologies, converged to transform the way a substantial proportion of humans reproduce. The purpose of this article is to describe the societal and demographic trends driving increased worldwide demand for IVF, as well as to provide an overview of emerging technologies that promise to greatly expand IVF utilization and lower its cost.

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“…Salivary tests, like urine tests, are a non-invasive option for home hormone monitoring [ 70 ]. Despite the similar benefits of these methods, salivary assays may be less convenient to patients, since the samples must be sent to a laboratory as the assay (enzyme-linked immunosorbent assay) cannot be done at home [ 5 , 70 ]. This then adds to the time that clinicians and patients will have to wait for test results to become available.…”

Section: Urine-based Hormonal Assaysmentioning

confidence: 99%

“…This then adds to the time that clinicians and patients will have to wait for test results to become available. Like urinary tests, salivary E2 correlates well with serum E2; however, salivary P4 correlates poorly with serum P4, decreasing the potential applications of this measurement [ 5 ].…”

Section: Urine-based Hormonal Assaysmentioning

confidence: 99%

Self-Monitoring of Urinary Hormones in Combination with Telemedicine — a Timely Review and Opinion Piece in Medically Assisted Reproduction

et al. 2021

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Cycle monitoring via ultrasound and serum-based hormonal assays during medically assisted reproduction (MAR) can provide information on ovarian response and assist in optimizing treatment strategies in addition to reducing complications such as ovarian hyperstimulation syndrome (OHSS). Two surveys conducted in 2019 and 2020, including overall 24 fertility specialists from Europe, Asia and Latin America, confirmed that the majority of fertility practitioners routinely conduct hormone monitoring during MAR. However, blood tests may cause inconvenience to patients. The reported drawbacks of blood tests identified by the survey included the validity of results from different service providers, long waiting times and discomfort to patients due to travelling to clinics for tests and repeated venepunctures. Historically, urine-based assays were used by fertility specialists in clinics but were subsequently replaced by more practical and automated serum-based assays. A remote urine-based hormonal assay could be an alternative to current serum-based testing at clinics, reducing the inconvenience of blood tests and the frequency of appointments, waiting times and patient burden. Here we provide an overview of the current standard of care for cycle monitoring and review the literature to assess the correlation between urine-based hormonal assays and serum-based hormonal assays during MAR. In addition, in this review, we discuss the evidence supporting the introduction of remote urine-based hormonal monitoring as part of a novel digital health solution that includes remote ultrasound and tele-counselling to link clinics and patients at home.

show abstract

A multi-centre international study of salivary hormone oestradiol and progesterone measurements in ART monitoring

Cited by 17 publications

References 30 publications

Not within spitting distance: Salivary immunoassays of estradiol have subpar validity for predicting cycle phase

Not within spitting distance: Salivary immunoassays of estradiol have subpar validity for predicting cycle phase

The Future of IVF: The New Normal in Human Reproduction

Self-Monitoring of Urinary Hormones in Combination with Telemedicine — a Timely Review and Opinion Piece in Medically Assisted Reproduction

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