A Multi-pumping Flow System for Fast Spectrophotometric Determination of Simvastatin

Melchert, Wanessa R.; Batista, Alex D.; Pereira, Andréia C.; Rocha, Diogo L.; Rocha, Fábio R.P.

doi:10.2174/1573412911309010015

Cited by 1 publication

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The objective of the present study is to develop and validate new simple, sensitive, rapid, reliable and precise spectrophotometric methods for the analysis of CP in its dosage forms. Furthermore, the methods have strictly followed some of the well known guidelines and methods [24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Application of Charge Transfer Reactions for the Quantitative Spectrophotometric Determination of Cyclophosphamide in Pure and Pharmaceutical Formulation

Siddappa

Hanamshetty²

2015

CPA

View full text Add to dashboard Cite

The present investigation describes two simple, sensitive and validated spectrophotometric methods for the determination of Cyclophosphamide (CP) in pure and formulated forms. The methods are mainly based on the formation of charge transfer (CT) complex, with the reagents 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) (Method A) and p-Chloranilic acid (PCA) (Method B), hence a stable, 1:1 stoichiometric complex was obtained, which shows orangeyellow and pink colors, respectively. The produced chromogens optical densities were measured at 352 and 522 nm, respectively. The Beer's law was tested in the range of 2-16 and 5-50 µg mL -1 . The optical characteristics such as molar absorptivity (ɛ), and Sandell's sensitivity values were calculated. Other analytical parameters like, Limit of Detection (LOD), Limit of Quantification (LOQ), accuracy and precisions were evaluated. The proposed methods were successfully applied for the determination of the CP in tablet formulation with higher accuracy, better recoveries and less than 2% relative standard deviation.

show abstract

Section: Introductionmentioning

confidence: 99%