A Multicenter Phase II Study of Local Radiation Therapy for Stage IEA Mucosa-Associated Lymphoid Tissue Lymphomas: A Preliminary Report From the Japan Radiation Oncology Group (JAROG)

Long-Term Outcomes and Patterns of Relapse of Early-Stage Extranodal Marginal Zone Lymphoma Treated With Radiation Therapy With Curative Intent

“…A report of 86 patients with stage IE orbital MZL mostly treated with single-modality RT showed 98.7% in-field RFS at 10 years; 6 patients had a contralateral orbital relapse, all salvaged with RT (13). A small, prospective, multicenter phase 2 trial of RT in stage IEA MZL also found that RT was safe and efficacious, with a 3-year OS of 100% and a local control of 97% (5). Other groups have reported outcomes of patients with various MZL stages and subtypes (6, 7, 10-12) without a focus on early-stage extra-nodal MZL treated with RT as curative intent.…”

“…The existing literature has drawn different conclusions about the optimal treatment regimen for this disease. In addition, there is no consensus on the prognostic value of disease site, stage, risk groups, and other patient characteristics at diagnosis (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Radiation therapy as single-modality treatment is highly effective for local control and organ preservation of early-stage extranodal MZL.…”

Radiation for MALT of the Submandibular Gland

“…Overall, this paper observed that radiotherapy alone was effective in treating EMZL, with low relapse rates and a 10-year survival of 78%. In a phase II study, 37 patients with stage IE extragastric MALT lymphomas including orbit, salivary gland, and thyroid were treated with RT [18]. The median RT dose delivered was 30.6 Gy.…”

Transition of thyroid autoantibodies by rituximab treatment for thyroid MALT lymphoma

“…In Tsang's series, patients with extranodal MALT lymphomas had an overall 5-year survival of 98% and a disease-free survival of 77% with radiation therapy alone [19]. Moderate dose radiation therapy (25 to 30 Gy) was highly effective without severe side effects in achieving local control with acceptable morbidity with MALT lymphoma [20]. However, case 3 was diagnosed with thyroid MALT lymphoma after radiation therapy of total 63 Gy in the neck.…”