A multicenter, randomized controlled trial comparing a single intra-articular injection of Gel-200, a new cross-linked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee

Strand, Vibeke; Baraf, Herbert S. B.; Lavin, P. T.; Lim, Sang Yup; Hosokawa, Hiroyuki

doi:10.1016/j.joca.2012.01.013

Cited by 97 publications

(100 citation statements)

References 26 publications

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“…In terms of maximum mouth opening, it reduced from 30.15 mm at t 0 (range, 26-40 mm; SD, 4.44) to 37.54 mm at t 1 (range, 31-51 mm; SD, 5.10), with an increase of 7.38 mm (range, 4-11 mm; SD, 2.02) and a highly significant difference (P < 0.0001). At t 2 , it was 39.54 mm (range,(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51) SD, 4.55) with an increase of 9.38 mm (range, 5-12 mm; SD, 2.21) compared with t 0 and that of 2.00 mm compared with t 1 . Both differences in the results are statistically significant (P < 0.0001 and P < 0.01, respectively).…”

mentioning

confidence: 96%

Temporomandibular Joint Disorders Treated With Articular Injection

Giacomello

Giacomello²,

Mortellaro³

et al. 2015

Journal of Craniofacial Surgery

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The objective of this study was to evaluate the effectiveness of the temporomandibular joint (TMJ) osteoarthritis treatment through articular injections of plasma rich in growth factors (PGRF)-Endoret. Thirteen patients (median age, 47.64 y; SD, 7.51; range, 40-64 y; male-female ratio, 2:11) with osteoarthritis of TMJ associated to chronic pain have been selected. They were treated with articular injections of PRGF-Endoret, measuring the maximum mouth opening and pain level before the first injection (t0), 30 days after just before the second (t1), and after 6 months (t2). Data were analyzed using the paired Student's t-test data. The visual analogue scale score at t0 is 7.69 (range, 4-10; SD, 1.9), whereas that at t1 is 1.54 (range, 0-5; SD, 1.74) and that at t2 is 0.23 (range, 0-2; SD, 0.65). These differences in the results are statistically highly significant (P < 0.0001 comparison t0-t1 and t0-t2 and P < 0.01 comparison t1-t2). In terms of maximum mouth opening, it reduced from 30.15 mm at t0 (range, 26-40 mm; SD, 4.44) to 37.54 mm at t1 (range, 31-51 mm; SD, 5.10), with an increase of 7.38 mm (range, 4-11 mm; SD, 2.02) and a highly significant difference (P < 0.0001). At t2, it was 39.54 mm (range, 34-51; SD, 4.55) with an increase of 9.38 mm (range, 5-12 mm; SD, 2.21) compared with t0 and that of 2.00 mm compared with t1. Both differences in the results are statistically significant (P < 0.0001 and P < 0.01, respectively). The articular injections of PRGF-Endoret represent a very efficient method to control pain and to improve the TMJ mobility.

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mentioning

confidence: 96%

Temporomandibular Joint Disorders Treated With Articular Injection

Giacomello

Giacomello²,

Mortellaro³

et al. 2015

Journal of Craniofacial Surgery

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“…Compared with HA, HA gel is effective in retarding hydrolytic degradation, has less viscosity, and resides in the tissue longer (7 days). 7,34,44 This HA derivative has been shown to be a potent inhibitor of tumor necrosis factor-a (TNFa) and TNFb. 7,8 HA gel is currently used as an adjuvant therapy to prevent postoperative adhesions after laparotomic, laparoscopic, and hysteroscopic abdominopelvic surgical procedures.…”

mentioning

confidence: 99%

“…7,8 Compared with HA, HA gel effectively retards hydrolytic degradation, has less viscosity, remains longer in tissues, and is resorbed via HA's pathways within 7 days. 7,44 HA gels have been widely investigated and clinically used in obstetrics, gynecology, abdominopelvic surgery, and orthopedics; however, no research has been conducted to investigate its efficacy in epidural fibrosis.…”

mentioning

confidence: 99%

Effects of cross-linked high-molecular-weight hyaluronic acid on epidural fibrosis: experimental study

Işık

Taşkapılıoğlu²,

Atalay³

et al. 2015

SPI

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OBJECT Epidural fibrosis is nonphysiological scar formation, usually at the site of neurosurgical access into the spinal canal, in the intimate vicinity of and around the origin of the radicular sheath. The formation of dense fibrous tissue causes lumbar and radicular pain. In addition to radicular symptoms, the formation of scar tissue may cause problems during reoperation. The authors aimed to investigate the effects of cross-linked high-molecular-weight hyaluronic acid (HA), an HA derivative known as HA gel, on the prevention of epidural fibrosis by using histopathological and biochemical parameters. METHODS Fifty-six adult female Sprague-Dawley rats were evaluated. The rats were divided into 4 groups. Rats in the sham group (n = 14) underwent laminectomy and discectomy and received no treatment; rats in the control group (n = 14) underwent laminectomy and discectomy and received 0.9% NaCl treatment in the surgical area; rats in the HA group (n = 14) received HA treatment at the surgical area after laminectomy and discectomy; and rats in the HA gel group (n = 14) underwent laminectomy and discectomy in addition to receiving treatment with cross-linked high-molecular-weight HA in the surgical area. All rats were decapitated after 4 weeks, and the specimens were evaluated histopathologically and biochemically. The results were statistically compared using the Mann-Whitney U-test. RESULTS Compared with the sham and control groups, the HA and HA gel groups showed significantly lower fibroblast cell density and tissue hydroxyproline concentrations (p < 0.05). There was statistically significant lower dural adhesion and foreign-body reaction between the control and HA gel groups (p < 0.05). Granulation tissue and epidural fibrosis were significantly lower in the HA and HA gel groups compared with the sham group (p < 0.05). There were no significant differences in any histopathological parameters or biochemical values between Groups 3 and 4 (p > 0.05). CONCLUSIONS Cross-linked high-molecular-weight HA had positive effects on the prevention of epidural fibrosis and the reduction of fibrotic tissue density. The efficacy of this agent should also be verified in further experimental and clinical studies.

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“…W piśmiennictwie nie brakuje prac, w których oceniono efekt wiskosuplementacji po podaniu kwasu hialuronowego tylko do jednego stawu kolanowego [20,21,22], ale tylko w nielicznych badaniach zastosowano tę metodę do obu kolan równocześnie [23]. W ramach badania wykonano trzy iniekcje preparatu kwasu hialuronowego w odstępach tygodniowych oraz czwartą iniekcję po 12 tygodniach.…”

Section: Ys K U Sj Aunclassified

Viscosupplementation for the treatment of osteoarthritis of the knee

Ostałowska¹,

Skowron²,

Birkner³

et al. 2017

Ann. Acad. Med. Siles.

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W S T Ę P:Choroba zwyrodnieniowa stawów kolanowych (gonartroza -GA) należy do najczęstszych schorzeń narządu ruchu, a ból i ograniczenie ruchomości kolana są najdotkliwiej odbieranymi przez pacjentów objawami zmian zwyrodnieniowych. Celem pracy było sprawdzenie, czy podanie dostawowe preparatu kwasu hialuronowego wpływa na funkcje stawu kolanowego, wybrane parametry układu antyoksydacyjnego i natężenie stresu oksydacyjnego we krwi u pacjentów z gonartrozą. M A T E R I A Ł I M E T O D Y:Grupa badana 1K obejmowała 96 pacjentów z chorobą zwyrodnieniową stawu kolanowego, którym podano kwas hialuronowy do jednego stawu kolanowego, natomiast do grupy badanej 2K włączono 33 pacjentów, którym podano kwas hialuronowy do obu stawów kolanowych. Badanie prowadzono przez 40 tygodni według ustalonego protokołu. Oznaczono całkowity status oksydacyjny (TOS) osocza, zawartość grup sulfhydrylowych (SH) w surowicy, aktywność katalazy (CAT) w erytrocytach, aktywność dysmutazy ponadtlenkowej (SOD) w osoczu i erytrocytach, aktywność peroksydazy glutationowej (GPx) w erytrocytach. W Y N I K I: Po leczeniu wiskosuplementacyjnym odnotowano zmniejszenie nasilenia bólu oraz poprawę w badanych skalach VAS i HHS, przy czym nieco większą poprawę stwierdzono w przypadku zajęcia jednego kolana. Po leczeniu dostawowym kwasem hialuronowym stwierdzono znamienny spadek aktywności SOD oraz CAT a wzrost aktywności GPx, wzrost stężenia grup SH w obu grupach oraz spadek stężenia TOS. WNIOSKI: Wiskosuplementacja w chorobie zwyrodnieniowej stawu kolanowego istotnie redukuje ból kolana i poprawia jego funkcje oraz wywołuje korzystne zmiany w układzie antyoksydacyjnym krwi. Efekt leczenia jest porównywalny zarówno w przypadku podawania preparatu kwasu hialuronowego do jednego, jaki i do obu stawów kolanowych. S Ł O W A K L U C Z O W Echoroba zwyrodnieniowa stawu kolanowego, kwas hialuronowy, reaktywne formy tlenu, enzymy antyoksydacyjne

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A multicenter, randomized controlled trial comparing a single intra-articular injection of Gel-200, a new cross-linked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee

Abstract: ClinicalTrials.gov NTC 00449696.

Cited by 97 publications

References 26 publications

Temporomandibular Joint Disorders Treated With Articular Injection

Temporomandibular Joint Disorders Treated With Articular Injection

Effects of cross-linked high-molecular-weight hyaluronic acid on epidural fibrosis: experimental study

Viscosupplementation for the treatment of osteoarthritis of the knee

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