2009
DOI: 10.1136/sti.2009.038075
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A multicentre, randomised, double-blind, placebo controlled study of cryotherapy versus cryotherapy and podophyllotoxin cream as treatment for external anogenital warts

Abstract: Results: 70 patients per group were randomised and started treatment; 101 firstepisode warts, 91 male. No treatment-related serious adverse events were reported.Follow-up at week 12 was 85%. By intention-to-treat analysis, clearances at 4 and 12 weeks were higher in the combination group (60.0% and 60.0% respectively) than with cryotherapy alone (45.7%, 45.7%) although not statistically significant (relative risk 1.31; 95% CI 0.95, 1.81). By week 24 there was no difference between the groups (68.6% and 64.3% r… Show more

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Cited by 41 publications
(30 citation statements)
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“…During the cryotherapy procedure, liquid nitrogen freezes the tissue and thereby causes necrosis; the treatment also stimulates specific immune responses, such as an immunomodulatory action of T lymphocytes against the remaining viable wart tissue (5,6). The advantages of cryotherapy are that it is simple, inexpensive, rarely causes scarring or depigmentation, and is safe for use in pregnancy.…”
Section: Introductionmentioning
confidence: 99%
“…During the cryotherapy procedure, liquid nitrogen freezes the tissue and thereby causes necrosis; the treatment also stimulates specific immune responses, such as an immunomodulatory action of T lymphocytes against the remaining viable wart tissue (5,6). The advantages of cryotherapy are that it is simple, inexpensive, rarely causes scarring or depigmentation, and is safe for use in pregnancy.…”
Section: Introductionmentioning
confidence: 99%
“…Another compound found in the extract was palmitic acid, which induces mitochondrial pore opening and leads to a decrease of the mitochondrial membrane potential and then to cell death (Belosludtsev et al, 2006). Additionally, podophyllotoxin has been widely used topically in ethanolic solution and creams in the treatment of skin infections (Gilson et al, 2009;Lacey et al, 2003). This may be related to the antileishmanial activity in vivo, as the extract prevents the growth of the lesion without causing irritation or skin damage.…”
Section: Discussionmentioning
confidence: 99%
“…An abundant amount of literature is available on the use of cryotherapy for treatment of cutaneous [12] and anogenital warts [9,[13][14][15][16]. Within this small spectrum of reports even fewer studies have been published about cryotherapy use for treatment of oral condyloma acuminatum.…”
Section: Discussionmentioning
confidence: 99%