A multicommuted flow system for dissolution studies of Captopril in pharmaceutical preparations

Sanchez, Mariana Amorim; Rocha, Diogo L.; Melchert, Wanessa R.; Rocha, Fábio R.P.

doi:10.1590/s0103-50532011000500002

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…Apesar de resultados distintos terem sido obtidos para cada fármaco, a melhor resposta, considerando o sinal analítico e a reprodutibilidade, foi obtida em pH 7,0, no qual o sistema tampão apresenta sua maior capacidade tamponante. Este pH coincide com o empregado em estudos anteriores, [13][14][15][16][17] exceto no caso da determinação de proteínas. 12 O comprimento do reator afeta tanto o tempo de residência, quanto a dispersão da amostra.…”

Section: Otimização Das Variáveisunclassified

Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos

Schmidt¹,

Melchert²,

Rocha³

2011

Quím. Nova

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Recebido em 17/12/10; aceito em 3/3/11; publicado na web em 5/5/11 A POLIVALENT FLOW SYSTEM FOR THE SPECTROPHOTOMETRIC DETERMINATION OF PHARMACEUTICALS. A flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) with 2,2′-biquinoline 4,4′-dicarboxylic acid. Linear responses were achieved in the μmol L -1 range, with coefficients of variation better than 1.7%. Sampling rate was estimated as 60 determinations per hour, consuming 230 μg of BQA and generating 2.5 mL of waste per determination. Results for commercial samples agreed with those obtained by procedures recommended by the American and European pharmacopeias at the 95% confidence level.

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Section: Otimização Das Variáveisunclassified

Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos

Schmidt¹,

Melchert²,

Rocha³

2011

Quím. Nova

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“…Existing analytical methods to detect uric acid in biofluids include spectroscopy, chromatography, electrochemistry, membrane and capillary electrophoresis (Gochman and Schmitz, 1971 ; Kageyama, 1971 ; Kabasakalian et al, 1973 ; Inoue et al, 2003 ; Perelló et al, 2005 ; Cooper et al, 2006 ; Arora et al, 2009 ; Uricase/PAP test, 2009 ; Bhawna and Pundir, 2010 ; Rocha and Rocha, 2010 ; Amir et al, 2011 ; Sanchez et al, 2011 ; Sidorova and Grigoriev, 2012 ; Hamzah et al, 2013 ; WitkowskaNery et al, 2016 ). Most conventional spectrophotometric methods for uric acid detection involve colorimetric enzymatic reaction, where.…”

Section: Introductionmentioning

confidence: 99%

“…uric acid is oxidized in the presence of uricase and forms allantoin (C4H6N4O3), carbon dioxide and hydrogen peroxide (Gochman and Schmitz, 1971 ; Kageyama, 1971 ; Kabasakalian et al, 1973 ; Uricase/PAP test, 2009 ; Rocha and Rocha, 2010 ; Hamzah et al, 2013 ). In addition, researchers have reported a spectrophotometric method based on the reduction of Cu(II) ions to Cu(I) ions in presence of urinary uric acid (Rocha and Rocha, 2010 ; Sanchez et al, 2011 ). Amir et al have reported a flow injection spectrophotometric method based on the reduction of potassium ferricyanide in presence of uric acid to potassium ferrocyanide (Amir et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Developing Paper Based Diagnostic Technique to Detect Uric Acid in Urine

et al. 2018

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Urinary or serum uric acid concentration is an indicator of chronic kidney condition. An increase in uric acid concentration may indicate renal dysfunction. Reliable instantaneous detection of uric acid without requiring sophisticated laboratory and analytical instrumentation, such as: chromatographic and spectrophotometric methods, would be invaluable for patients with renal complication. This paper reports the early development of a simple, low-cost, instantaneous and user-friendly paper based diagnostic device (PAD) for the qualitative and quantitative detection of uric acid in urine. A colorimetric detection technique was developed based on the intensity of Prussian blue color formation on paper in presence of uric acid; the reaction rate of corresponding chemical reactions on paper surface was also studied. Based on the colorimetric signal produced on paper surface, a calibration curve was developed to detect unknown concentration of uric acid in urine. The effect of temperature on formation of color signal on paper surface was also analyzed. In this study, estimation of urinary uric acid using MATLAB coding on a windows platform was demonstrated as the use of software application and digital diagnostics. This paper-based technique is faster and less expensive compared to traditional detection techniques. The paper-based diagnostic can be integrated with a camera of smart phone, tablet computer or laptop and an image processing application (using windows/android/IOS platform) as a part of digital diagnostics. Therefore, with proper calibration, the paper-based technique can be compatible and economical to the sophisticated detection techniques used to detect urinary uric acid.

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“…Because of its importance for human health, a variety of analytical procedures for its determination have been proposed, employing separation techniques such as high‐performance liquid chromatography (HPLC) and capillary electrophoresis . The following procedures have been employed as detection techniques: voltammetry , spectrophotometry and chemiluminescence .…”

Section: Introductionmentioning

confidence: 99%

Development of a new procedure for the determination of captopril in pharmaceutical formulations employing chemiluminescence and a multicommuted flow analysis approach

et al. 2015

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This paper describes a new technique for the determination of captopril in pharmaceutical formulations, implemented by employing multicommuted flow analysis. The analytical procedure was based on the reaction between hypochlorite and captopril. The remaining hypochlorite oxidized luminol that generated electromagnetic radiation detected using a homemade luminometer. To the best of our knowledge, this is the first time that this reaction has been exploited for the determination of captopril in pharmaceutical products, offering a clean analytical procedure with minimal reagent usage. The effectiveness of the proposed procedure was confirmed by analyzing a set of pharmaceutical formulations. Application of the paired t-test showed that there was no significant difference between the data sets at a 95% confidence level. The useful features of the new analytical procedure included a linear response for captopril concentrations in the range 20.0-150.0 µmol/L (r = 0.997), a limit of detection (3σ) of 2.0 µmol/L, a sample throughput of 164 determinations per hour, reagent consumption of 9 µg luminol and 42 µg hypochlorite per determination and generation of 0.63 mL of waste. A relative standard deviation of 1% (n = 6) for a standard solution containing 80 µmol/L captopril was also obtained.

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A multicommuted flow system for dissolution studies of Captopril in pharmaceutical preparations

Cited by 3 publications

References 16 publications

Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos

Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos

Developing Paper Based Diagnostic Technique to Detect Uric Acid in Urine

Development of a new procedure for the determination of captopril in pharmaceutical formulations employing chemiluminescence and a multicommuted flow analysis approach

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