A multidisciplinary approach to the early detection of ovarian carcinoma: Rationale, protocol design, and early results

Karlan, Beth Y.; Raffel, Leslie J.; Crvenković, Gordan; Smrt, Cindy; Chen, M. Dwight; Lopez, Eloise; Walla, Catherine A.; Garber, Carrie; Cane, Patricia A.; Sarti, Dennis A.; Rotter, Jerome I.; Piatt, Lawrence D.

doi:10.1016/0002-9378(93)90607-k

Cited by 70 publications

(15 citation statements)

References 26 publications

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“…Previous studies of ovarian carcinoma screening in women at increased risk have demonstrated similar rates of abnormalities in both transvaginal ultrasounds [12][13][14] and CA 125 assessments 7,15 as were seen in the current series, suggesting that the high rate of abnormalities seen was not secondary to an unusually low threshold for diagnosing abnormal findings. An important factor that may contribute to the rate of abnormal ovarian ultrasounds both in our cohort and other populations at increased risk is that a substantial portion of the participants in these studies have a personal history of breast carcinoma and may have received either cytotoxic chemotherapy and/or tamoxifen.…”

Section: Discussionsupporting

confidence: 79%

Ovarian carcinoma screening in women at intermediate risk

Kauff

Hurley

Hensley

et al. 2005

Cancer

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Objective: To analyze the frequency of the haplotypes of β‐globin gene cluster in randomly selected patients withsickle cell disease (SCD), attended in the Children's Hospital of Panama. Methods: Five polymorphic sites in the β‐globin gene cluster were analyzed by polymerase chain reaction (PCR) followed by restriction digestion and agarose gel electrophoresis in a total of 100 patients, including 95 homozygous for HbS (sickle cell anemia) and 5 compound heterozygotes for HbS and HbC genes (HbSC disease). Results: The Bantu haplotype was predominant with a frequency of 51%, followed by the Benin (30%), Senegal (8.5%), and Cameroon (4%); other haplotypes were also identified. Genotype was CAR/CAR in 39 patients, BEN/BEN in 22, SEN/SEN in 6, CAM/CAM in 4, ARB/ARB in 1, CAR/BEN in 15, CAR/SEN in 5, CAR/Hp5 in 3, CAR/Hp1 in 1, BEN/Hp11 in 1, Atp Hp1/Hp1 in 2, and Atp Hp5/Hp5 in 1 individual. Hemoglobin concentrations, hematocrit, and mean corpuscular hemoglobin concentration values did not differ among homozygous forms of haplotypes. The mean HbF in all patients was 15.39 ± 1.21, whereas SEN/SEN patients had higher HbF than BEN/BEN patients (24.26 ± 4.18 vs. 13.17 ± 2.39, respectively, P < 0.05). The percentage of reticulocytes was highest in BEN/BEN and CAR/CAR, and it was associated with worst prognosis. Conclusion: The results show the presence of common βS haplotypes in Panama; the prevalence of African origin, and the similarity in the Panamanian and Colombian distribution of haplotypes. Am. J. Hum. Biol. 2011. © 2011 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 79%

Ovarian carcinoma screening in women at intermediate risk

Kauff

Hurley

Hensley

et al. 2005

Cancer

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“…These numbers show the importance of finding reliable tests to detect early ovarian cancer. As stated so clearly by one of the leaders in the field of gynecologic oncology: ''It has been estimated that shifting just 10% of ovarian cancer cases from stage III to stage I by early detection would produce a greater improvement in disease survival than the introduction of cisplatin or taxol chemotherapy'' [24]. Currently there are no such screening techniques available.…”

Section: Ovarian Cancermentioning

confidence: 99%

Angiogenesis in normal and neoplastic ovaries

et al. 2005

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Ovarian physiology is intricately connected to hormonally regulated angiogenic response. Recent advances in the post genomic revolution have significantly impacted our understanding of ovarian function. In an angiogenesis perspective, the ovary offers a unique opportunity to unravel the molecular orchestration of blood vessel development and regression under normal conditions. A majority of ovarian cancers develop from the single layer of epithelium surrounding the ovaries. Angiogenesis is critical for the development of ovarian cancer and its peritoneal dissemination. The present review summarizes recent findings on the angiogenic response in neoplastic ovaries and discusses the prospects of using anti-angiogenic approaches to treat ovarian cancer.

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“…Studies of high-risk women participating in high-risk screening programs have generally focused their reports on the effectiveness of screening tests [Karlan et al, 1993;Muto et al, 1993;Karlan, 1997;Crump et al, 2000]. Reports that characterize these women have described high levels of perceived risk and worry about their risk for ovarian cancer [Robinson et al, 1997;Trask et al, 2001].…”

Section: Introductionmentioning

confidence: 99%

Worry about ovarian cancer risk and use of screening by high‐risk women: How you recruit affects what you find

Andersen

Nelson

Peacock

et al. 2004

American J of Med Genetics Pt A

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Several studies have described the characteristics of women at high-risk for ovarian cancer who are participating in registry studies and high-risk screening programs. These studies have found high-risk women to report high levels of perceived risk and worry about their risk for ovarian cancer. In contrast, population based studies have found that while high-risk women did report high levels of perceived risk, they did not report high levels of worry about their risk. In this study, we examine reports of perceived risk, worry about ovarian cancer, and use of screening by high-risk women recruited to participate in a survey from several recruitment sources. These sources include self-, physician-, and affected patient relative-referral, a fundraising mailer, and a mass mailing to a commercial mailing list. High-risk women recruited via mass mailing were less likely than those recruited via physicians or affected relatives to report either worry about their risk or use of ovarian cancer screening tests.

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A multidisciplinary approach to the early detection of ovarian carcinoma: Rationale, protocol design, and early results

Cited by 70 publications

References 26 publications

Ovarian carcinoma screening in women at intermediate risk

Ovarian carcinoma screening in women at intermediate risk

Angiogenesis in normal and neoplastic ovaries

Worry about ovarian cancer risk and use of screening by high‐risk women: How you recruit affects what you find

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