2010
DOI: 10.1128/iai.00174-10
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A Multiepitope Subunit Vaccine Conveys Protection against Extraintestinal PathogenicEscherichia coliin Mice

Abstract: Infections due to extraintestinal pathogenic Escherichia coli (ExPEC) are common in humans and animals and include urinary tract infections (from uropathogenic E. coli [UPEC]), septicemia, and wound infections. These infections result in significant morbidity and mortality and in high health care costs. In view of the increasing number of ExPEC infections and the ever-growing antibiotic resistance capability of ExPEC isolates, preventive measures such as an effective vaccine against ExPEC are desirable. An ExP… Show more

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Cited by 90 publications
(87 citation statements)
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“…We found that E. coli isolates responsible for VAP harbored iroN more often than those responsible for respiratory tract colonization, showing the unprecedented potential role of iroN in lung pathogenicity. Further studies are required to confirm and clarify the respective roles played by these VF, but our findings are consistent with the choice of iron uptake proteins as potential candidates for vaccines against E. coli as recently published [32].…”
Section: Discussionsupporting
confidence: 75%
See 1 more Smart Citation
“…We found that E. coli isolates responsible for VAP harbored iroN more often than those responsible for respiratory tract colonization, showing the unprecedented potential role of iroN in lung pathogenicity. Further studies are required to confirm and clarify the respective roles played by these VF, but our findings are consistent with the choice of iron uptake proteins as potential candidates for vaccines against E. coli as recently published [32].…”
Section: Discussionsupporting
confidence: 75%
“…[23] e The virulence genes were grouped in pathogenicity islands (PAIs) and plasmid as in Ref. [51] as follow: grey = plasmid, blue = PAI I CFT073 , orange = PAI II J96 , green = PAI III 536 , violet = high-pathogenicity island (PAI IV 536 ) f Antibiotypes defined for each patient according to a given pattern of antibioresistance provide potential leads to investigate future therapeutic strategies such as those based on vaccine candidates [30][31][32][33].…”
Section: Discussionmentioning
confidence: 99%
“…Intranasal administration of these antigens in mice elicited both systemic and mucosal immune responses that included the production of antigen-specific IgM, IgG and IgA antibodies, cytokine responses and protection against UTI in the mouse model (Alteri et al, 2009). A similar study was also conducted by Wieser et al (2010), where they evaluated the use of a subunit vaccine against extra intestinal E. coli. Using a novel approach of computer-aided design, two completely artificial genes were created, both encoding eight peptide domains derived from these extra intestinal E. coli proteins.…”
Section: Vaccinesmentioning
confidence: 98%
“…Wieser et al(2010) reported that an ideal vaccine target against uropathogens should be (i) exposed on the bacterial surface and (ii) widely distributed among clinical isolates but not among commensal strains of the gut flora, (iii) possess epitopes that are conserved across diverse strains, and (iv) elicit a protective immune response. Additional desirable characteristics of an effective vaccine target include increased expression at the site of infection and a role in the pathogenesis of disease (Wieser et al, 2010). Several studies have investigated the use of potential antigens as targets for vaccine development against UPEC.…”
Section: Vaccinesmentioning
confidence: 99%
“…The low-specificity exhibited by these hybrid trimers suggests the need for chaperone intervention during transit across the periplasmic space. Future experiments utilising the immunoglobulin binding properties of EibD (Sandt and Hill, 2000, Leo and Goldman, 2009b Virulence factors targeted in these trials have included capsule polysaccharides (Kumar et al, 2005, Straube et al, 1986, O-antigen (Uehling and Wolf, 1969, Russo et al, 2007, Billips et al, 2009, Russo et al, 2009), α-haemolysin (O'Hanley et al, 1991, Moriel et al, 2010, Smith et al, 2015, CNF-1 (Smith et al, 2015), iron acquisition receptors (Russo et al, 2003, Wieser et al, 2010, Wieser et al, 2012, Durant et al, 2007, Alteri et al, 2009) and fimbrial adhesins (Langermann et al, 1997, Langermann et al, 2000, Goluszko et al, 2005, Roberts et al, 2004. Despite these extensive efforts, there is still no effective vaccine against UPEC.…”
Section: Growth Characteristics Of Mg1655 Periplasmic Chaperone Mutanmentioning
confidence: 99%