A multifunctional carbon dot-based nanoplatform for bioimaging and quaternary ammonium salt/photothermal synergistic antibacterial therapy

Chu, Xiaohong; Zhang, Pan; Liu, Yihan; Huang, Xinrong; Zhou, Ninglin; Shen, Jing; Meng, Na

doi:10.1039/d1tb02717d

Cited by 30 publications

(22 citation statements)

References 46 publications

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“…In a series of reports, heteroatom-doped CDs with excellent fluorescence emission were hybridized with curcumin ( Figure 1C ), and methylene blue as common photosensitizers (PS), which enhanced of the ROS generation, water solubility of the applied PS, and the photothermal heat generation for bacterial inactivation ( Yan et al, 2021 ; Lv et al, 2022 ; Wen et al, 2022 ). Similarly, Wen et al, demonstrated that CDs modified with quaternary ammonium salt can simultaneously provide photothermal antibacterial activity and wound healing without any inflammatory damage to surrounding tissues ( Chu et al, 2022 ). Moniruzzaman et al prepared polychromatic CDs by changing the acidic strength of the CDs synthesis reaction.…”

Section: Photothermal Applicationsmentioning

confidence: 99%

Carbon dots for photothermal applications

2022

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Carbon dots are zero-dimensional nanomaterials that have garnered significant research interest due to their distinct optical properties, biocompatibility, low fabrication cost, and eco-friendliness. Recently, their light-to-heat conversion ability has led to several novel photothermal applications. In this minireview, we categorize and describe the photothermal application of carbon dots along with methods incorporated to enhance their photothermal efficiency. We also discuss the possible mechanisms by which the photothermal effect is realized in these carbon-based nanoparticles. Taken together, we hope to provide a comprehensive landscape highlighting several promising research directions for using carbon dots for photothermal applications.

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Section: Photothermal Applicationsmentioning

confidence: 99%

Carbon dots for photothermal applications

2022

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“…Antimicrobial CDs have also been developed by using traditional antibiotics and common antibacterial compounds as the raw materials to trade the old for the new, such as kanamycin sulfate [ 72 ], levofloxacin hydrochloride [ 73 , 74 ], quaternary ammonium compounds [ 22 , 48 , 49 , 75 , 76 ], and 2,4-dihydroxybenzoic acid [ 77 ]. Luo et al prepared CDs (termed CDs-Kan) from kanamycin sulfate by a one-step hydrothermal method [ 72 ].…”

Section: Antimicrobial Cdsmentioning

confidence: 99%

“…Only one kind of antimicrobial CDs with PTT capacity had been reported when we prepared the previous review. Since 2019, more CDs have been reported for antimicrobial PTT [ 76 , 100 , 101 ]. Belkahla et al produced CDs from glucose as the precursor through the alkali-assisted ultrasonic irradiation approach [ 100 ].…”

Section: Antimicrobial Cdsmentioning

confidence: 99%

Carbon Dots for Killing Microorganisms: An Update since 2019

Lin

Wang

2022

Pharmaceuticals

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Frequent bacterial/fungal infections and occurrence of antibiotic resistance pose increasing threats to the public and thus require the development of new antibacterial/antifungal agents and strategies. Carbon dots (CDs) have been well demonstrated to be promising and potent antimicrobial nanomaterials and serve as potential alternatives to conventional antibiotics. In recent years, great efforts have been made by many researchers to develop new carbon dot-based antimicrobial agents to combat microbial infections. Here, as an update to our previous relevant review (C 2019, 5, 33), we summarize the recent achievements in the utilization of CDs for microbial inactivation. We review four kinds of antimicrobial CDs including nitrogen-doped CDs, metal-containing CDs, antibiotic-conjugated CDs, and photoresponsive CDs in terms of their starting materials, synthetic route, surface functionalization, antimicrobial ability, and the related antimicrobial mechanism if available. In addition, we summarize the emerging applications of CD-related antimicrobial materials in medical and industry fields. Finally, we discuss the existing challenges of antimicrobial CDs and the future research directions that are worth exploring. We believe that this review provides a comprehensive overview of the recent advances in antimicrobial CDs and may inspire the development of new CDs with desirable antimicrobial activities.

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“…The antibacterial mechanisms of CDs with positive charges mainly include the generation of reactive oxygen species (ROS), the destruction of bacterial cell walls, the destruction of genomic DNA and so on [17,18]. It is not easy to induce bacterial resistance, which is very attractive compared to conventional antibacterial drug coatings [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

A novel antibacterial and fluorescent coating composed of polydopamine and carbon dots on the surface of orthodontic brackets

Wang

Ding

et al. 2023

J Mater Sci: Mater Med

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Many kinds of antibacterial coatings have been designed to prevent the adherence of bacteria onto the surface of a fixed orthodontic device of brackets. However, the problems such as weak binding force, undetectable, drug resistance, cytotoxicity and short duration needed to be solved. Thus, it has great value in developing novel coating methods with long-term antibacterial and fluorescence properties according to the clinical application of brackets. In this study, we synthesized blue fluorescent carbon dots (HCDs) using the traditional Chinese medicinal honokiol, which could cause irreversible killing effects on both gram-positive and gram-negative bacteria through positive charges on the surface and inducing reactive oxygen species (ROS) production. Based on this, the surface of brackets was serially modified with polydopamine and HCDs, taking advantage of the strong adhesive properties as well as the negative surface charge of polydopamine particles. It is found that this coating exhibits stable antibacterial properties in 14 days with good biocompatibility, which can provide a new solution and strategy to solve the series of hazards caused by bacterial adhesion on the surface of orthodontic brackets. Graphical Abstract

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A multifunctional carbon dot-based nanoplatform for bioimaging and quaternary ammonium salt/photothermal synergistic antibacterial therapy

Abstract: The emergence of drug resistance and superbugs poses a devastating threat to public health, even lead to death. Thus, it is significant to develop a novel antibacterial agent to combat...

Cited by 30 publications

References 46 publications

Carbon dots for photothermal applications

Carbon dots for photothermal applications

Carbon Dots for Killing Microorganisms: An Update since 2019

A novel antibacterial and fluorescent coating composed of polydopamine and carbon dots on the surface of orthodontic brackets

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