A Multinational Investigation of the Impact of Subcutaneous Sumatriptan

Heywood, J; Bouchard, Josée; Cortelli, Pietro; Dahlöf, Carl; Jansen, Jan-Peter; Pham, Sissi V.; Hirsch, Jameson K.; Edwards, C; Adams, Jim; Berto, Paula Pinheiro; Brüeggenjuergen, B; Nyth, Anna Lena; Lindsay, Patrice; Price, Kay

doi:10.2165/00019053-199700111-00004

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Cited by 16 publications

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“…—This questionnaire has been used as a primary endpoint in clinical trials of several pharmaceutical products. 26 A copy of the 5‐question instrument is in the .…”

Section: Methodsmentioning

confidence: 99%

Assessing the Impact of Migraine on Health‐Related Quality of Life: An Additional Use of the Quality of Well‐being Scale–Self‐administered

et al. 2000

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“…—This questionnaire has been used as a primary endpoint in clinical trials of several pharmaceutical products. 26 A copy of the 5‐question instrument is in the .…”

Section: Methodsmentioning

confidence: 99%

Assessing the Impact of Migraine on Health‐Related Quality of Life: An Additional Use of the Quality of Well‐being Scale–Self‐administered

et al. 2000

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“…These changes could occur either because of treatment or because of changes in the underlying headache disorder. As a result, while some open label longitudinal clinical trials have used HRQoL measurements as a primary outcome measure, 14 blinded clinical drug comparison trials generally use more traditional outcomes related to relief of head pain for the primary outcome measure. 15…”

Section: Why Measure Hrqol?mentioning

confidence: 99%

Assessing Health-Related Quality of Life in Patients with Migraine

Becker

2002

Can. J. Neurol. Sci.

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Background:The place of health-related quality of life (HRQoL) instruments in clinical research trials and clinical practice as compared to more traditional clinical outcome measures such as headache intensity and frequency is unclear.Objectives:To review the current status of HRQoL measurement in migraine.Methods:A literature search was done for HRQoL and migraine. Selected articles dealing with migraine and commonly used HRQoL instruments and HRQoL measures used in recent clinical trials were reviewed.Results:Several general and migraine specific HRQoLinstruments can detect changes over time in response to at least major changes in migraine therapy. Both also show a correlation with clinical headache features. However, their sensitivity to detect clinically significant changes over time is not clear.Conclusion:The SF-36, a general HRQoLmeasure and several migraine-specific HRQoL instruments are useful endpoints for migraine clinical trials. Their role in clinical practice is yet to be established.

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