“…Wang and Achenie (2002a) studied the molecular design of solvents for extractive fermentation including solvent attributes such as biocompatibility, inertness and phase splitting, introduced a group contribution framework which results in a conconvex MINLP model, studied a local MINLP algorithm, OA/ER/AP, and applied it to case studies on ethanol extractive fermentation. Dua, Bozinis, and Pistikopoulos (2002) proposed novel approaches for multiparametric mixed-integer quadratic models through the decomposition into a multiparametric quadratic MIQP model for the upper bound and a potentially nonconvex MINLP model for the lower bound, suggested ways of addressing the nonconvexity in the MINLP, and generated envelopes of parametric solutions and the enclosure of the multiparametric MIQP. Sahinidis, Tawarmalani, and Yu (2003) revisited the design of alternative refrigerants problem, introduced an integer formulation for previously described structural constraints, proposed new structural constraints between one-bonded and higher-bonded groups in the absence of rings and new clique constraints for rings, applied a branch-and-reduce global optimization algorithm with a modification so as to generate all feasible integer solutions, and generated new compounds for refrigerants.…”