A multiple fluorescence sensor with the sensitive recognition to human serum albumin

Abstract

A naphthalene-containing dicarboxylic ligand, 4-(carboxymethoxy)-6-methyl-1-(p-tolyl)-2-naphthoic acid (Hcmtna), is synthesized and used to construct a coordination compound, Co(H 2 O) 4 (cmtna) 2 (Co-cmtna), through the hydrothermal strategy. The moderate rigidity and flexibility of the organic molecule result a low coordination number of cobalt ion with the ligand and provide more possibilities for potential applications. Experimental results show that the fluorescence of Co-cmtna can be quenched by multiple objects, including antibiotics, pesticides, and metal ions, which make it possible as a multifunctional sensor. More interestingly, Co-cmtna has interactions with human serum albumin in the phosphate-buffered saline solution, which are detailed studied by the site binding model formula, thermodynamic formula, and Föster nonradiative energy transfer mechanism.

One-Pot Surface Modification of β-Cu2O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

“…The drug–protein interaction with bloodstream, serum, and plasma may cause the formation of a drug–protein complex that greatly influences the distribution, toxicity, and metabolism of drugs in the body. l -Ascorbic acid (LAA) transports various substances like bilirubin, fatty acids, metal ions, hormones, and exogenous drugs and functions mainly as a carrier protein for steroid and thyroid hormones that play a major role in stabilizing extracellular fluid volume by contributing to the oncotic pressure (colloid osmotic pressure) of plasma and in a class of mammals with diverse functions in the transportation of substances and the metabolism and distribution of exogenous and endogenous molecules . Bovine serum albumin (BSA) is mainly selected as an adequate protein model for drug–protein interaction due to its low cost, availability, morphological resemblance with human serum albumin, and high bonding sites to metal complexes …”