Water–rock interactions and scouring actions are recognized key factors that significantly influence the disintegration of rock on the surface of slopes. However, the research on rock disintegration, specifically under the action of scouring, is limited, which makes it difficult to understand the characteristics of rock disintegration. Therefore, in this study disintegration tests were performed on the gypsum karst breccia collected from the Zhoukoudian site in Beijing, using a self-made disintegration test device. Further, this study investigated the impact of solution pH, flow velocity, and the number of cycles on the characteristics of rock disintegration. The changes in pore structure, microstructure, and mineral composition of the rock were analyzed using nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), X-ray diffraction (XRD), and inductively coupled plasma optical emission spectrometer (ICP-OES) methods. The findings reveal that the cumulative relative disintegration amount of the gypsum karst breccia experiences an increase as the pH value of the soaking solution decreases and the number of cycles increases. Once a specific flow rate is attained, the cumulative relative disintegration amount stabilizes (about 73%) and no longer exhibits significant changes. This phenomenon signifies the presence of a stabilizing flow rate for disintegration. The stable flow rate concerning rock disintegration is influenced by both the solution’s pH and the number of cycles. Following acid contamination, the rock sample’s particle morphology undergoes disruption, leading to the dissolution of cement. This, in turn, leads to an augmented release of Ca2+, Al3+, and Ma2+ ions in the solution, intensifying the disintegration of the rock samples. Conversely, alkali contamination prompts secondary cementation, mitigating localized damage. This results in a marginal increase in the calcite content within the rock samples (from 15.3% to 19.2%), while the release of Ca2+ in the solution experiences a decrease. Additionally, there is a slight increase in the release of Al3+ (a maximum increase of 1.71 mg/L), which minimally inhibits the disintegration of the rock samples. Notably, the rock disintegration predominantly occurs around macropores, and the effect of solution pH on the disintegration characteristics and stable flow rate is primarily due to the changes in the relative proportion of macropore volume in the rock samples. The findings of this study have significant implications for the prediction and control of slope-related issues.