A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis

Göktepe, Serdar; Abilez, Oscar J.; Parker, Kevin Kit; Kuhl, Ellen

doi:10.1016/j.jtbi.2010.04.023

Cited by 199 publications

(240 citation statements)

References 52 publications

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“…This phenomenon is peculiar to cardiac fibers that are more likely to cause ventricular dilation during the diastolic filling, thus leading to a higher end-diastolic volume. Interestingly, both previous results are obtained without altering the mechanical parameters belonging to the strain energy function (5). Furthermore, for the hypertrophic fiber, the previous decrease in T max , which includes both active and passive components, occurs while the active tension T a in panel E of Figure 1 increases due to the higher values of λ e .…”

Section: The Mechanical Responsementioning

confidence: 54%

“…Since, during eccentric hypertrophy, F g should represent the cardiomyocytes elongation due to the serial deposition of new sarcomeres, we choose F g as in [4,5,7] (3)…”

Section: The Mechanical Modelmentioning

confidence: 99%

“…In the literature, there are a few recent studies addressing the problem of how eccentric hypertrophy can be mathematically modeled for the whole heart (e.g., [4][5][6][7]). However, they have mainly focused on the mechanical activity of hypertrophic hearts, disregarding the coupling with a model of bioelectrical activity, except from [4,7].…”

Section: Introductionmentioning

confidence: 99%

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Computational modeling of the electromechanical response of a ventricular fiber affected by eccentric hypertrophy

Bianco

Franzone

Scacchi

et al. 2017

Communications in Applied and Industrial Mathematics

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The aim of this work is to study the effects of eccentric hypertrophy on the electromechanics of a single myocardial ventricular fiber by means of a one-dimensional finite-element strongly-coupled model. The electrical current flow model is written in the reference configuration and it is characterized by two geometric feedbacks, i.e. the conduction and convection ones, and by the mechanoelectric feedback due to stretchactivated channels. First, the influence of such feedbacks is investigated for both a healthy and a hypertrophic fiber in case of isometric simulations. No relevant discrepancies are found when disregarding one or more feedbacks for both fibers. Then, all feedbacks are taken into account while studying the electromechanical responses of fibers. The results from isometric tests do not point out any notable difference between the healthy and hypertrophic fibers as regards the action potential duration and conduction velocity. The length-tension relationships show increased stretches and reduced peak values for tension instead. The tension-velocity relationships derived from afterloaded isotonic and quickrelease tests depict higher values of contraction velocity at smaller afterloads. Moreover, higher maximum shortenings are achieved during the isotonic contraction. In conclusion, our simulation results are innovative in predicting the electromechanical behavior of eccentric hypertrophic fibers.

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Section: The Mechanical Responsementioning

confidence: 54%

“…Since, during eccentric hypertrophy, F g should represent the cardiomyocytes elongation due to the serial deposition of new sarcomeres, we choose F g as in [4,5,7] (3)…”

Section: The Mechanical Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Computational modeling of the electromechanical response of a ventricular fiber affected by eccentric hypertrophy

Bianco

Franzone

Scacchi

et al. 2017

Communications in Applied and Industrial Mathematics

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“…Mechanical stimuli in the form of pressure overload and volume overload are believed to be the major driving forces that initiate cardiac remodeling and increase the risk for development of CHF and sudden death [2] . Pressure overload is often caused by high blood pressure and aortic stenosis.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin downregulation is associated with volume overload-induced myocyte dysfunction in rats

et al. 2015

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Aim: Adiponectin has been reported to exert protective effects during pathological ventricular remodeling, but the role of adiponectin in volume overload-induced heart failure remains unclear. In this study we investigated the effect of adiponectin on cardiac myocyte contractile dysfunction following volume overload in rats. Methods: Volume overload was surgically induced in rats by infrarenal aorta-vena cava fistula. The rats were intravenously administered adenoviral adiponectin at 2-, 6-and 9-weeks following fistula. The protein expression of adiponectin, adiponectin receptors (AdipoR1/R2 and T-cadherin) and AMPK activity were measured using Western blot analyses. Isolated ventricular myocytes were prepared at 12 weeks post-fistula to examine the contractile performance of myocytes and intracellular Ca 2+ transient. Results: A-V fistula resulted in significant reductions in serum and myocardial adiponectin levels, myocardial adiponectin receptor (AdipoR1/R2 and T-cadherin) levels, as well as myocardial AMPK activity. Consistent with these changes, the isolated myocytes exhibited significant depression in cell shortening and intracellular Ca 2+ transient. Administration of adenoviral adiponectin significantly increased serum adiponectin levels and prevented myocyte contractile dysfunction in fistula rats. Furthermore, pretreatment of isolated myocytes with recombinant adiponectin (2.5 µg/mL) significantly improved their contractile performance in fistula rats, but had no effects in control or adenoviral adiponectin-administered rats.Conclusion: These results demonstrate a positive correlation between adiponectin downregulation and volume overload-induced ventricular remodeling. Adiponectin plays a protective role in volume overload-induced heart failure.

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“…Area growth is also usually transversely isotropic, i.e., isotropic in the plane tangent to the surface [7,44]. In complex tissues with multiple fiber families growth can be orthotropic [12], or even generally anisotropic [29]. The driving force for growth can either be morphogenetic, mechanic, or a combination of both.…”

Section: Introductionmentioning

confidence: 99%

On the mechanics of thin films and growing surfaces

Holland¹,

Kosmata

Goriely

et al. 2013

Mathematics and Mechanics of Solids

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Many living structured are coated by thin films, which have distinct mechanical properties from the bulk. In particular, these thin layers may grow faster or slower than the inner core. Differential growth creates a balanced interplay between tension and compression and plays a critical role in enhancing structural rigidity. Typical examples with a compressive outer surface and a tensile inner core are the petioles of celery, caladium, or rhubarb. While plant physiologists have studied the impact of tissue tension on plant rigidity for more than a century, the fundamental theory of growing surfaces remains poorly understood. Here, we establish a theoretical and computational framework for continua with growing surfaces and demonstrate its application to classical phenomena in plant growth. To allow the surface to grow independently of the bulk, we equip it with its own potential energy and its own surface stress. We derive the governing equations for growing surfaces of zero thickness and obtain their spatial discretization using the finite element method. To illustrate the features of our new surface growth model we simulate the effects of growth-induced longitudinal tissue tension in a stalk of rhubarb. Our results demonstrate that different growth rates create a mechanical environment of axial tissue tension and residual stress, which can be released by peeling off the outer layer. Our novel framework for continua with growing surfaces has immediate biomedical applications beyond these classical model problems in botany: It can be easily extended to model and predict surface growth in asthma, gastritis, obstructive sleep apnoea, brain development, and tumor invasion. Beyond biology and medicine, surface growth models are valuable tools for material scientists when designing functionalized surfaces with distinct user-defined properties.

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A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis

Cited by 199 publications

References 52 publications

Computational modeling of the electromechanical response of a ventricular fiber affected by eccentric hypertrophy

Computational modeling of the electromechanical response of a ventricular fiber affected by eccentric hypertrophy

Adiponectin downregulation is associated with volume overload-induced myocyte dysfunction in rats

On the mechanics of thin films and growing surfaces

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