A mussel-inspired wet-adhesion hydrogel with hemostasis and local anti-inflammation for managing the development of acute wounds

Zhu, Jieyu; Zhong, Kaijing; Zong, Yuan; Wang, Shunhua; Yang, Hui‐Yu; Li, Zhen; Shi, Tao; Sun, Li‐Zhong; Yang, Jiaojiao; Li, Jiyao

doi:10.1016/j.matdes.2021.110347

Cited by 34 publications

(28 citation statements)

References 61 publications

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“…Therefore, wound closure, bleeding control, and suppression of inflammation at the right time are very important in the healing of acute wounds. [6,7] In chronic wounds, due to the high level of inflammation, healing is longer than acute wounds. However, many chronic wounds undergo a natural healing process, but the tissue lacks normal structural and functional properties.…”

Section: Wound Classificationmentioning

confidence: 99%

“…[3,[10][11][12][13][14] Chronic skin lesions are more common in older people due to diabetes and circulatory disorders, physical disability, and inactivity. [7] Failure to treat such patients in a timely manner will eventually lead to amputation of their lower limbs. Also according to statistics, the annual cost of treating 6.5 million diabetic patients is estimated at $ 25 billion in the US.…”

Section: Wound Classificationmentioning

confidence: 99%

“…Therefore, wound closure, bleeding control, and suppression of inflammation at the right time are very important in the healing of acute wounds. [ 6,7 ]…”

Section: Wound Classificationmentioning

confidence: 99%

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An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

Mirhaj

Labbaf

Tavakoli

et al. 2022

Macromolecular Bioscience

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A wound can be surgical cuts from an operation or due to accident and trauma. The infected wound, as a result of bacteria growth within the damaged skin, interrupts the natural wound healing process and significantly impacts the quality of life. Wound dressing is an important segment of the skincare industry with its economic burden estimated at $ 20.4 billion (in 2021) in the global market. The results of recent clinical trials suggest that the use of modern dressings can be the easiest, most accessible, and most cost‐effective way to treat chronic wounds and, hence, holds significant promise. With the sheer number of dressings in the market, the selection of correct dressing is confusing for clinicians and healthcare workers. The aim of this research is to review widely used types of antibacterial wound dressings, as well as emerging products, for their efficiency and mode of action. In this review, introducing antibiotics and antibacterial nanoparticles as two important and clinically widely used categories of antibacterial agents is focused. The perspectives and challenges for paving the way for future research in this field are also discussed.

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Section: Wound Classificationmentioning

confidence: 99%

Section: Wound Classificationmentioning

confidence: 99%

See 1 more Smart Citation

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

Mirhaj

Labbaf

Tavakoli

et al. 2022

Macromolecular Bioscience

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Section: Peg-inducedmentioning

confidence: 99%

“…The most used additives for the induction of SF assembly were summarized in this section. In addition, tannic acid, [103][104][105] peptide gelators, [106][107][108] carbon dioxide, 109,110 and various copolymers 111,112 were also employed as additives for the preparation of self-assembled SF hydrogels in various biomedical applications.…”

Section: Materials Advancesmentioning

confidence: 99%

Self-assembled silk fibroin hydrogels: from preparation to biomedical applications

2022

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Reversibly Adhesive, Anti‐Swelling, and Antibacterial Hydrogels for Tooth‐Extraction Wound Healing

Li,

Zhi,

Chen

et al. 2024

Adv Healthcare Materials

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Oral wound treatment faces challenges due to the complex oral environment such as moisture, bacteria and dynamic mechanics, thus, sealing wound quickly becomes necessary. Although some materials have achieved adhesion and antibacterial properties, how to effectively solve the contradiction between strong adhesion and on‐demand removal remains a challenge. Herein, a reversibly adhesive hydrogel was designed by free radical copolymerization of cationic monomer [2‐(acryloyloxy) ethyl] trimethylammonium chloride (ATAC), hydrophobic monomer ethylene glycol phenyl ether acrylate (PEA) and N‐isopropylacrylamide (NIPAAm). The cationic quaternary ammonium salts provide electrostatic interactions, the hydrophobic groups provide hydrophobic interactions, and the PNIPAAm chain segments provide hydrogen bonding, leading to strong adhesion. Therefore, the hydrogel obtains an adhesion strength of 18.67 KPa to oral mucosa, and could seal wound fast within 10 s. Furthermore, unlike pure PNIPAAm, the hydrogel has a LCST of 40.3 °C due to the contribution of ATAC and PEA, enabling rapid removal with 40 °C water after treatment. In addition, the hydrogel realizes excellent anti‐swelling ratio (∼ 80%) and antibacterial efficiency (over 90%). Animal experiments prove that the hydrogel effectively reduces inflammation infiltration, promotes collagen deposition and vascular regeneration. Thus, the hydrogel as a multi‐functional dressing has great application prospects in oral wound management.This article is protected by copyright. All rights reserved

show abstract

A mussel-inspired wet-adhesion hydrogel with hemostasis and local anti-inflammation for managing the development of acute wounds

Cited by 34 publications

References 61 publications

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

Self-assembled silk fibroin hydrogels: from preparation to biomedical applications

Reversibly Adhesive, Anti‐Swelling, and Antibacterial Hydrogels for Tooth‐Extraction Wound Healing

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