A mutagenic metabolite synthesized by Salmonella typhimurium grown in the presence of azide is azidoalanine

Physical, chemical and environmental properties of selected chemical alternatives for the pre‐plant use of methyl bromide as soil fumigant

“…Azide is metabolized in barley and bacteria to yield a stable mutagenic metabolite, L ‐azido alanine, but mammalian cells do not convert azide to this product. It appears that azide substitutes for sulfide, the natural substrate in this reaction in plants, but animal cells utilize L ‐methionine rather than sulfide and lack the O ‐acetyl serine (thiol)‐lyase that is essential in the synthesis of L ‐azidoalamine 126, 127. It is not known whether such a metabolite would be found as a pesticide residue.…”

2-Azido-1-(3,6-dichloro-9H-fluoren-1-yl)ethanone

“…For the mutagenic activity of azides, see: Sander & Muehlbour (1977); Nilan et al (1973); Owais et al (1983). For the preparation of 1,2,3-triazoles via 1,3-dipolar cycloaddition reactions of azides with substituted acetylene compounds, see: Purvisis et al (1984); Patei & Smalley (1984).…”

“…Azide derivatives have been used in rubber vulcanization, polymer cross linking, dyes tire cord adhesives, forming of plastics, pharmaceuticals, pesticides and herbicides. Many azide compounds show mutagenic activities (Sander & Muehlbour, 1977;Nilan et al, 1973;Owais et al, 1983). The chemistry of azides has thus attracted the attention of many chemists, since many of these compounds play an important role in organic chemistry.…”

1,3‐Dipolar Cycloaddition Reactions of Substituted Benzyl Azides with Acetylenic Compounds

“…Azide derivatives have been used in rubber vulcanization, polymer crosslinking, dyes, tire cored adhesives, foaming of plastics, pharmaceuticals, pesticides and herbicides [1]. Many azide compounds show mutagenic activities [2][3][4].…”