A myo-inositol diet for lung cancer prevention and beyond

Roh, Jae Il; Lee, Han Woong

doi:10.21037/jtd.2018.08.143

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…For example, myo-inositol a well-known carbocyclic sugar that is widely used in health-promoting supplement formulations and abundant in fresh fruit is among the most abundant metabolites both in MVs and juice. More recently, myo-inositol was also used as an adjuvant for conventional chemotherapy due to its proven anti-tumorigenic properties [ 35 ]. Quinic acid, a well-known nutraceutical and anticancer drug candidate in clinical phase trial was also identified among the highly abundant components in the grapefruit juice and MVs samples.…”

Section: Resultsmentioning

confidence: 99%

Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line

Stanly

Alfieri

Ambrosone

et al. 2020

Cells

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Fruit juice is one of the most easily accessible resources for the isolation of plant-derived vesicles. Here we found that micro- and nano-sized vesicles (MVs and NVs) from four Citrus species, C. sinensis, C. limon, C. paradisi and C. aurantium, specifically inhibit the proliferation of lung, skin and breast cancer cells, with no substantial effect on the growth of non-cancer cells. Cellular and molecular analyses demonstrate that grapefruit-derived vesicles cause cell cycle arrest at G2/M checkpoint associated with a reduced cyclins B1 and B2 expression levels and the upregulation of cell cycle inhibitor p21. Further data suggest the inhibition of Akt and ERK signalling, reduced intercellular cell adhesion molecule-1 and cathepsins expressions, and the presence of cleaved PARP-1, all associated with the observed changes at the cellular level. Gas chromatography-mass spectrometry-based metabolomics reveals distinct metabolite profiles for the juice and vesicle fractions. NVs exhibit a high relative amount of amino acids and organic acids whereas MVs and fruit juice are characterized by a high percentage of sugars and sugar derivatives. Grapefruit-derived NVs are in particular rich in alpha–hydroxy acids and leucine/isoleucine, myo-inositol and doconexent, while quininic acid was detected in MVs. Our findings reveal the metabolite signatures of grapefruit-derived vesicles and substantiate their potential use in new anticancer strategies.

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Section: Resultsmentioning

confidence: 99%

Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line

Stanly

Alfieri

Ambrosone

et al. 2020

Cells

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“…The pilot human trial (26 subjects) revealed a statistically significant regression of dysplasia in participants treated with myo-inositol [177]. Mechanistic and in vivo studies suggested the benefit of using of myo-inositol in Kras mutated high-risk smokers [178,179].…”

Section: Modulators Of Signaling Pathwaysmentioning

confidence: 99%

Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview

Ashraf-Uz-Zaman

Bhalerao

Mikelis

et al. 2020

Cancers

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Chemoprevention of lung cancer is thought to significantly reduce the risk of acquiring these conditions in the subpopulation of patients with underlying health issues, such as chronic obstructive pulmonary disorder and smoking-associated lung problems. Many strategies have been tested in the previous decades, with very few translating to successful clinical trials in specific subpopulations of patients. In this review, we analyze these strategies, as well as new approaches that have emerged throughout the last few years, including synthetic lethality concept and microbiome-induced regulation of lung carcinogenesis. Overall, the continuous effort in the area of lung chemoprevention is required to develop practical therapeutical approaches. Given the inconsistency of results obtained in clinical trials targeting lung cancer chemoprevention in various subgroups of patients that differ in the underlying health condition, race, and gender, we believe that individualized approaches will have more promise than generalized treatments.

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“…74 Its antitumorigenic effects on lung cancer cells could include a reduction in the expression of mutant KRAS, a change in the tumor microenvironment through the recruitment of polarized (M1-like) macrophages at tumor sites and regulation of interleukin-6 (IL-6) secretion. 75 • The polysaccharide astragalus (APS), isolated from the root of the Astragalus membranaceus, used in Traditional Chinese Medicine, can suppress human non-small cell cancer cells by downregulating p65 and p50, reducing the transcription of NF-κB (active in NSCLC) and reducing the level of Bcl-xL protein expression in A549 cells 76 ; APS induces apoptosis by blocking the ERK pathway in NSCLC 77 and NSCLC H460 cells through suppression of notch1 and notch3 and subregulation of Bcl-2, 78 increases proapoptotic Bax levels (activation of caspase-3 and caspase-9 in H1299 cells). 79,80 • Apigenin is a flavonoid with several properties: it is antioxidant, proapoptotic, 81,82 and causes ROS accumulation with apoptosis induction of approximately 30% in cancer cells pulmonary H1299, H460, and H2030.…”

Section: Phytotherapeutics For Lung Cancermentioning

confidence: 99%

Integrative Treatment of Lung Cancer Patients: Observational Study of 57 Cases

Anelli¹,

Nardo²,

Bonucci³

2021

ASJO

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Introduction A retrospective clinical study was performed to identify the characteristics of patients with lung cancer treated with integrative cancer treatment in addition to conventional medicine. Materials and Methods We reviewed medical records for lung cancer patients who visited a single integrative setting in Rome, Italy. A total of 57 patients were included, and the majority had advanced-stage cancer. All of them underwent integrative therapy with nutrition and phytotherapy indications. The diet was designed to reduce most of possible factors promoting cancer proliferation, inflammation, and obesity. Foods with anti-inflammatory, prebiotic, antioxidant, and anticancer properties had been chosen. Herbal supplements with known effects on lung cancer were prescribed. In particular, astragal, apigenine, fucosterol, polydatin, epigallocatechin gallate, cannabis, curcumin, and inositol were used. Furthermore, medical mushrooms and other substances were used to improve the immune system and to reduce chemotherapy side effects. Five key parameters have been evaluated for 2 years starting at the first surgery: nutritional status, immune status, discontinuation of therapy, quality of life, and prognosis of the disease. Results A relevant improvement in parameters relative to nutritional status, immune status, and quality of life has been observed after integrative therapy compared with the same parameters at the first medical visit before starting such approach. Conclusion The results suggest that integrative therapy may have benefits in patients with lung cancer. Even though there are limitations, the study suggests that integrative therapy could improve nutritional status and quality of life, with possible positive effect on overall survival.

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A myo-inositol diet for lung cancer prevention and beyond

Cited by 4 publications

References 23 publications

Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line

Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line

Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview

Integrative Treatment of Lung Cancer Patients: Observational Study of 57 Cases

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