Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview

Abstract

Chemoprevention of lung cancer is thought to significantly reduce the risk of acquiring these conditions in the subpopulation of patients with underlying health issues, such as chronic obstructive pulmonary disorder and smoking-associated lung problems. Many strategies have been tested in the previous decades, with very few translating to successful clinical trials in specific subpopulations of patients. In this review, we analyze these strategies, as well as new approaches that have emerged throughout the last few years, including synthetic lethality concept and microbiome-induced regulation of lung carcinogenesis. Overall, the continuous effort in the area of lung chemoprevention is required to develop practical therapeutical approaches. Given the inconsistency of results obtained in clinical trials targeting lung cancer chemoprevention in various subgroups of patients that differ in the underlying health condition, race, and gender, we believe that individualized approaches will have more promise than generalized treatments.

Cancer chemoprevention through Frizzled receptors and EMT

“…Cancer chemoprevention is a developing field with the potential to have significant health impacts for populations at high risk of cancer [ 137 ]. The characterization of potential targets for prevention agents is a critical area of research.…”

Smoking status during first‐line immunotherapy and chemotherapy in NSCLC patients: A case–control matched analysis from a large multicenter study

“…Programmed death 1 (PD‐1) checkpoint inhibitors have become the backbone of the treatment algorithm of nononcogene addicted non‐small cell lung cancer (NSCLC) patients 1 . Tobacco use is known to be the main risk factor for lung cancer development and is related to a high all‐cause morbidity and mortality overall 2 . Nevertheless, smoking of tobacco has been associated with improved outcomes in NSCLC patients receiving checkpoint inhibitors across different lines and regardless of programmed death‐ligand 1 (PD‐L1) tumor expression 3 .…”

Benzo[a]pyrene diol epoxide‐induced transformed cells identify the significance of hsa_circ_0051488, a ERCC1‐derived circular RNA in pulmonary squamous cell carcinoma

“…Early diagnosis and treatment are essential to improving the survival rate and quality of life in these patients. Researches have attributed the onset and progression of lung cancer to interactions between endogenous factors and life style factors, in particular tobacco use 3,4 …”