Pharmaceutical
contamination is an emerging environmental concern
that threatens global health and impacts every hemisphere of existence.
The extensive exploitation and unregulated release of these chemical
pollutants challenge environmental sustainability and call for their
immediate detection and remediation. This study discusses the electrochemical
determination of the antiprotozoal drug (dimetridazole), which is
banned in numerous places owing to suspicions of it being carcinogenic,
using a 2D/2D heterojunction. The detrimental outcomes of the drug
demonstrate the significance of its effective detection and the development
of suitable materials for the sensing application. The deep eutectic
solvent-based fabrication of Ni–Fe layered double hydroxide
nanosheets/sulfur-doped graphitic carbon nitride heterostructure features
the green and ecologically benign synthesis of the compound with remarkable
properties. The conjunction of hierarchical structures offers synergistic
quantum confinement effects and confines charge carriers promoting
abundant active sites. The improved electrocatalytic activity of the
proposed drug sensor reinforces its perspectives by exhibiting higher
sensitivity,
wide linear-range responses (0.008–110.77 μM), a lower
limit of detection (1.6 nM), appreciable stability, and higher selectivity.
Analysis of real samples with the developed electrocatalyst underpins
its practical applications in the real world. The development of superior
architectures with lower energy requirements and minimal byproducts
marks the superior characteristics of the synthesis methodology within
the guidelines of green chemistry.