A nanolayer coating on polydimethylsiloxane surfaces enables a mechanistic study of bacterial adhesion influenced by material surface physicochemistry

Pan, Fei; Altenried, Stefanie; Liu, Mengdi; Hegemann, Dirk; Bülbül, Ezgi; Moeller, Jens; Schmahl, Wolfgang W.; Maniura‐Weber, Katharina; Ren, Qun

doi:10.1039/c9mh01191a

Cited by 33 publications

(60 citation statements)

References 59 publications

(45 reference statements)

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“…For measuring the WCA on PEG, a thin layer of the liquid was applied to a glass slide. The values for PDMS and PEG correspond well with values known from literature [ 59 , 61 , 79 , 80 ]…”

Section: Resultssupporting

confidence: 86%

“…For measuring the WCA on PEG, a thin layer of the liquid was applied to a glass slide. The values for PDMS and PEG correspond well with values known from literature [59,61,79,80] Even if the applied plasma processes differ for the two types of samples, they are quite similar in the resulting surface properties concerning hydrophilicity. Again, the effect of draining duration on the successful attachment of PEG, as discussed earlier, becomes clearly apparent.…”

Section: Wca Measurementssupporting

confidence: 86%

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Plasma Processing of Low Vapor Pressure Liquids to Generate Functional Surfaces

et al. 2020

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The concept of depositing solid films on low-vapor pressure liquids is introduced and developed into a top-down approach to functionalize surfaces by attaching liquid polyethylene glycol (PEG). Solid-liquid gradients were formed by low-pressure plasma treatment yielding cross-linking and/or deposition of a plasma polymer film subsequently bound to a flexible polydimethylsiloxane (PDMS) backing. The analysis via optical transmission spectroscopy (OTS), optical, confocal laser scanning (CLSM) and scanning electron microscopy (SEM), Fourier transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) as well as by water contact angle (WCA) measurements revealed correlations between optical appearance, chemical composition and surface properties of the resulting water absorbing, covalently bound PEG-functionalized surfaces. Requirements for plasma polymer film deposition on low-vapor pressure liquids and effective surface functionalization are defined. Namely, the thickness of the liquid PEG substrate was a crucial parameter for successful film growth and covalent attachment of PEG. The presented method is a practicable approach for the production of functional surfaces featuring long-lasting strong hydrophilic properties, making them predestined for non-fouling or low-friction applications.

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“…For measuring the WCA on PEG, a thin layer of the liquid was applied to a glass slide. The values for PDMS and PEG correspond well with values known from literature [ 59 , 61 , 79 , 80 ]…”

Section: Resultssupporting

confidence: 86%

Section: Wca Measurementssupporting

confidence: 86%

Plasma Processing of Low Vapor Pressure Liquids to Generate Functional Surfaces

et al. 2020

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“…Both high deposition rates (e.g., for water‐repellent coatings on textiles) and low deposition rates (e.g., for nm‐thick cover layers for diffusion control) were targeted. [ 35,75,76 ] Hence, varying deposition conditions over a broad range of power input, monomer gas flow rate, pressure, and plasma volume were applied. In the following, these results as well as literature data are revisited in light of the introduced formalism.…”

Section: Resultsmentioning

confidence: 99%

“…[ 30,32,33 ] Recently, nm‐thick HMDSO‐derived PPFs have been applied as surface chemistry‐defining cover layers to gain new insights into protein and bacteria adhesion. [ 34,35 ] Noteworthy, water intrusion was found to affect biomolecule adsorption, whereas the mechanical properties of the substrate material appeared to be of less importance. Furthermore, HMDSO plasma‐modified hydrogels allow for the controlled release of drugs.…”

Section: Introductionmentioning

confidence: 99%

Plasma polymerization of hexamethyldisiloxane: Revisited

Hegemann

Bülbül

Hanselmann

et al. 2020

Plasma Processes & Polymers

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Activation reactions of molecules in plasma are investigated using plasma polymerization of hexamethyldisiloxane as a model system for plasma‐state polymerization. Underlying reaction pathways and film‐forming mechanisms are revisited based on a simplified macroscopic approach, considering the average energy available per monomer particle, Epl, in relation to the threshold energy, Eth, which represents an activation barrier for plasma polymerization. Basic principles are discussed involving averaged values for collision frequency, cross‐section, and reaction rate to produce film‐forming species combining macroscopic and microscopic quantities. Considering the energy uptake from the electric field by the electrons, the energy transfer from electrons to monomer molecules, and the conversion into film‐forming species, it is demonstrated that Epl/Eth is equally relevant as the electron energy distribution function for plasma‐chemical activation reactions.

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“…24 Several studies have reported that the modulus of PDMS can be adjusted by altering the ratio of crosslinking. [29][30][31][32][33][34] However, as the ratio of crosslinking agent is reduced, the amount of un-crosslinked PDMS molecules is increased. Consequently, free molecules of silicone oils can migrate to the surface and cause various problems, such as increased adhesion between PDMS and substrate, 35 or formation of a phase-separated liquid meniscus.…”

Section: Introductionmentioning

confidence: 99%