A nanoscale polymolybdate built by two hexavacant Keggin-type fragments via a novel {Ca6P6O38} cluster with β-sheet conformation modulation ability

Hua, Jiai; Wei, Xian; Bian, Yujian; Ma, Xiang; Li, Hao; Sun, Jierui; Fan, Jun; Niu, Yulan; Wang, Yanqing

doi:10.1039/d2ce00215a

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…Recent research has noted that the oxidation catalytic activity of Keggin-type POM fragments is remarkable [26,27] and that it could potentially facilitate the catalyzation of transition-metal ion-triggered production of ROS [28]. Moreover, these POMs can induce the formation of poly-nuclearity clusters of transition metal ions and, further, maintain these clusters for relatively long times [29]. Therefore, a hybrid molecule originating from Keggin-type POMs partnered with poly-nuclearity Zn clusters has the potential to retain the best characteristics of both base constituents, while also exhibiting additional positive characteristics.…”

Section: Introductionmentioning

confidence: 99%

A Novel Tri-Coordination Zinc Complex Functionalized Silicotungstate with ROS Catalytic Ability and Anti-Tumor Cells Activity

Hua

Wang

et al. 2022

Catalysts

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Reactive oxygen species (ROS) can be used as an effective method to treat tumors. Artificial oxidase has received increasing attention as a catalyst for ROS generation in fields ranging from bioinorganic chemistry to pharmaceutical chemistry. In this study, an artificial oxidase based on a binuclear zinc complex and Keggin-type silicotungstate [Zn2(4,4′-bpy)(Phen)2][SiW12O40] (ZSW) (4,4′-bpy = 4,4′-bipyridine; Phen = 1,10-phenanthroline) was synthesized and structurally featured in terms of its X-ray photoelectron spectrum (XPS), bond valence sum (Σs) calculation, IR spectra, and single-crystal X-ray diffraction (SXRD). ZSW is an ionic compound in which the cation is a binuclear zinc complex [Zn2(4,4′-bpy)(Phen)2]4+ and the anion is a α-Keggin-type silicotungstate [SiW12O40]4– cluster. Notably, the Zn ions in the [Zn2(4,4′-bpy)(Phen)2] exist in tri-coordination, which was first obtained in polyoxometalate (POM) chemistry. It was also demonstrated that ZSW is capable of efficiently catalyzing the production of ROS, which, according to the computational calculations, may be due to the synergistic action of zinc complexes and POM building blocks. Furthermore, ZSW exhibited inhibition ability toward ROS-sensitive tumor cells, such as PC12 cells.

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Section: Introductionmentioning

confidence: 99%

A Novel Tri-Coordination Zinc Complex Functionalized Silicotungstate with ROS Catalytic Ability and Anti-Tumor Cells Activity

Hua

Wang

et al. 2022

Catalysts

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A hexa-Cu cluster sandwiched silicotungstate with reactive oxygen species catalytic ability and anti-tumor activity in PC12 cells

Ma¹,

Wei²,

Wang³

et al. 2022

Journal of Molecular Structure

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A Nanoenzyme Constructed from Manganese and Strandberg-Type Phosphomolybdate with Versatility in Antioxidant and Modulating Conformation of Aβ Protein Misfolding Aggregates In Vitro

Hua

Wang

Wei

et al. 2023

IJMS

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Amyloid β-peptide (Aβ) misfolding aggregates with β-sheet structures and surplus reactive oxygen species (ROS) are both considered to be the culprit of neuronal toxicity in Alzheimer’s disease (AD). Therefore, modulating the misfolding mode of Aβ and inhibiting ROS simultaneous has become an important method for anti-AD. Herein, a nanoscale manganese-substituted polyphosphomolybdate (H2en)3[Mn(H2O)4][Mn(H2O)3]2[P2Mo5O23]2·14.5H2O (abbreviated as MnPM) (en = ethanediamine) was designed and synthesized by single crystal to single crystal transformation method. MnPM can modulate the β-sheet rich conformation of Aβ aggregates, and thus reduce the formation of toxic species. Moreover, MnPM also possesses the ability to eliminate the free radicals produced by Cu2+-Aβ aggregates. It can inhibit the cytotoxicity of β-sheet-rich species and protect synapses of PC12 cells. MnPM combines the conformation modulating ability of Aβ and anti-oxidation ability, which makes a promising multi-funcational molecular with a composite mechanism for the new conceptual designing in treatment of such protein-misfolding diseases.

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A nanoscale polymolybdate built by two hexavacant Keggin-type fragments via a novel {Ca₆P₆O₃₈} cluster with β-sheet conformation modulation ability

Abstract: A novel sandwich-type phosphomolybdate based on two hexavacant Keggin-type building block [PMo6O28]15– incorporating a novel hexagonal calcium phosphorus oxygen cluster {Ca6P6O38} was successfully synthesized. It can modulate the β-sheet-rich misfolding...

Cited by 4 publications

References 57 publications

A Novel Tri-Coordination Zinc Complex Functionalized Silicotungstate with ROS Catalytic Ability and Anti-Tumor Cells Activity

A Novel Tri-Coordination Zinc Complex Functionalized Silicotungstate with ROS Catalytic Ability and Anti-Tumor Cells Activity

A hexa-Cu cluster sandwiched silicotungstate with reactive oxygen species catalytic ability and anti-tumor activity in PC12 cells

A Nanoenzyme Constructed from Manganese and Strandberg-Type Phosphomolybdate with Versatility in Antioxidant and Modulating Conformation of Aβ Protein Misfolding Aggregates In Vitro

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