2021
DOI: 10.21037/apm-20-1971
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A narrative review of COVID-19: magnesium isoglycyrrhizinate as a potential adjuvant treatment

Abstract: Coronavirus disease 2019 (COVID-19) has become a global pandemic affecting more than 200 countries with 87 million patients worldwide as of January 7, 2021. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) replicates in a large amount and reaches high-titer levels in a short time after the infection. COVID-19 caused by SARS-CoV-2 shows clinical symptoms mainly including fever, fatigue, dry cough, and dyspnea. In more severe COVID-19 patients, viral pneumonia characterized by bilateral ground glass… Show more

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Cited by 9 publications
(8 citation statements)
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References 137 publications
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“…MgIG has a variety of pharmacological activities, including anti-inflammatory, antioxidant, antiviral and immune regulation 27 , 28 . It has a protective effect on the injury of important organs (such as liver and lung), and was recommended as supportive care for mild and common patients of atypical pneumonia 15 . In this study, the rat COPD model was successfully established in terms of increased levels of IL-6 and TNF-α in serum and decline of lung function (FEV 0.3 /FVC ratio), which were used as biomarkers and the main criterion for COPD patients 29 and well evidenced by the followed hispathological analysis (Fig.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…MgIG has a variety of pharmacological activities, including anti-inflammatory, antioxidant, antiviral and immune regulation 27 , 28 . It has a protective effect on the injury of important organs (such as liver and lung), and was recommended as supportive care for mild and common patients of atypical pneumonia 15 . In this study, the rat COPD model was successfully established in terms of increased levels of IL-6 and TNF-α in serum and decline of lung function (FEV 0.3 /FVC ratio), which were used as biomarkers and the main criterion for COPD patients 29 and well evidenced by the followed hispathological analysis (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Magnesium isoglycyrrhizinate (MgIG) has been applied to the clinical treatment of chronic inflammatory disease, such as hepatitis and pneumonia 13 , 14 , attributed to its glucocorticoid-like chemical structure. In particular, it has been recently recommended as supportive care for mild and common patients of coronavirus disease 2019 (COVID-19) 15 . And, we found that MgIG could alleviate the inflammatory response in COPD rats through reducing the release of the inflammatory cytokines in a COPD rat model 16 .…”
Section: Introductionmentioning
confidence: 99%
“…Magnesium isoglycyrrhizinate (MgIG) is a magnesium salt mainly composed of 18α-glycyrrhizic acid stereoisomers ( Figure 1A ) and belongs to the fourth generation of glycyrrhizic acid preparations. As a novel glycyrrhizic acid extracted from the traditional Chinese medicine licorice, MgIG has anti-inflammatory, antioxidant, antiviral, immunoregulatory and hepatocellular protective effects ( Tang et al, 2021 ). MgIG can protect the liver by regulating lipid metabolism in a mouse model of nonalcoholic fatty liver disease ( Jiang et al, 2020 ), and MgIG can inhibit hepatotoxicity by inhibiting oxidative stress, inflammation, and apoptosis in a mouse model of arsenic trioxide induced acute liver injury ( Liu et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…Glycyrrhizin is the most potent component in licorice, and it is found naturally as a mixture of the potassium and calcium salts of glycyrrhizic acid. Diammonium glycyrrhizinate (DG) is an ammonium salt of glycyrrhizic acid that is used medically in China as a third generation of glycyrrhizic acid [ 20 ]. Saponins isolated from licorice have been reported to stimulate high levels of humoral and cellular immunity [ 21 , 22 ].…”
Section: Introductionmentioning
confidence: 99%